Sequence in raw or FASTA format:
KANSL1 KAT8 regulatory NSL complex subunit 1 [Homo sapiens (human)]
|Entrez Gene ID||284058|
|Full Name||KAT8 regulatory NSL complex subunit 1|
|Synonyms||CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012].|
|REACT_172633||Chromatin modifying enzymes|
|REACT_172610||HATs acetylate histones|
|Homo sapiens (human)||KANSL1||NP_001180395.1|
|Pan troglodytes (chimpanzee)||KANSL1||XP_001137659.2|
|Macaca mulatta (Rhesus monkey)||KANSL1||XP_001115950.1|
|Canis lupus familiaris (dog)||KANSL1||XP_003435236.1|
|Bos taurus (cattle)||KANSL1||XP_003587505.1|
|Mus musculus (house mouse)||Kansl1||NP_001074514.1|
|Rattus norvegicus (Norway rat)||Kansl1||XP_006247613.1|
|Gallus gallus (chicken)||KANSL1||XP_003642834.2|
|Danio rerio (zebrafish)||LOC567884||XP_696283.4|
|Xenopus (Silurana) tropicalis (western clawed frog)||LOC100485168||XP_002935569.2|
|GO:0043981||histone H4-K5 acetylation||IDA|
|GO:0043982||histone H4-K8 acetylation||IDA|
|GO:0043984||histone H4-K16 acetylation||IDA|
|GO:0000123||histone acetyltransferase complex||IDA|
|GO:0043995||histone acetyltransferase activity (H4-K5 specific)||IDA|
|GO:0043996||histone acetyltransferase activity (H4-K8 specific)||IDA|
|GO:0046972||histone acetyltransferase activity (H4-K16 specific)||IDA|
What is the normal function of the KANSL1 gene?
The KANSL1 gene provides instructions for making a member (subunit) of a group of interacting proteins called the KAT8 regulatory NSL complex. This complex is categorized as a histone acetyltransferase (HAT) complex. It helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes.
The protein produced from the KANSL1 gene is found in most organs and tissues of the body before birth and throughout life. By its involvement in controlling the activity of other genes, this protein plays an important role in the development and function of many parts of the body.
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