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GPS2 G protein pathway suppressor 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004489 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

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Gene Symbol GPS2
Entrez Gene ID 2874
Full Name G protein pathway suppressor 2
Synonyms AMF-1, MGC104294, MGC119287, MGC119288, MGC119289
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13

Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601935

mRNA Protein Product Sequence Price Select
NM_004489, 53832030 NP_004480, 4758472 G protein pathway suppressor 2 ORF Sequence $400.00
KEGG
hsa05166HTLV-I infection
Homo sapiens (human)GPS2NP_004480.1
Pan troglodytes (chimpanzee)GPS2XP_511971.3
Macaca mulatta (Rhesus monkey)LOC721816XP_002800321.1
Canis lupus familiaris (dog)LOC100855803XP_003639092.1
Bos taurus (cattle)GPS2NP_001069242.1
Mus musculus (house mouse)Gps2NP_062700.2
Rattus norvegicus (Norway rat)Gps2NP_001017477.1
Danio rerio (zebrafish)gps2NP_957267.1
GeneCards GPS2
PDB 2L5G
UniProt Q13227
MIM 601935
Ensembl ENSG00000132522
HGNC 4550
HPRD 11878

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
G protein pathway suppressor 2
Names
G protein pathway suppressor 2
GPS-2

Interactant



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