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GPS2 G protein pathway suppressor 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu04401 NM_004489 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu04401C NM_004489 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol GPS2
Entrez Gene ID 2874
Full Name G protein pathway suppressor 2
Synonyms AMF-1
General protein information
Preferred Names
G protein pathway suppressor 2
Names
G protein pathway suppressor 2
GPS-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13

Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601935

mRNA Protein Product Sequence Price Select
NM_004489, 53832030 NP_004480, 4758472 G protein pathway suppressor 2 ORF Sequence $400.00
KEGG
hsa05166HTLV-I infection
Homo sapiens (human)GPS2NP_004480.1
Pan troglodytes (chimpanzee)GPS2XP_511971.3
Macaca mulatta (Rhesus monkey)LOC721816XP_002800321.1
Canis lupus familiaris (dog)GPS2XP_003639092.1
Bos taurus (cattle)GPS2NP_001069242.1
Mus musculus (house mouse)Gps2NP_062700.2
Rattus norvegicus (Norway rat)Gps2NP_001017477.1
Danio rerio (zebrafish)gps2NP_957267.1
Xenopus (Silurana) tropicalis (western clawed frog)gps2NP_001107718.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000188inactivation of MAPK activityTAS
GO:0007049cell cycleTAS
GO:0007254JNK cascadeTAS
GO:0046329negative regulation of JNK cascadeIDA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0017053transcriptional repressor complexIDA
Function
IDNameEvidence
GO:0003714transcription corepressor activityIDA
GO:0005095GTPase inhibitor activityTAS
GO:0005515protein bindingIPI
GeneCards GPS2
PDB 2L5G
UniProt Q13227
Vega OTTHUMG00000102198
MIM 601935
Ensembl ENSG00000132522
HGNC 4550
HPRD 11878

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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