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Blast Method:


SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001151 Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4), mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

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Gene Symbol SLC25A4
Entrez Gene ID 291
Full Name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Synonyms 1, AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, T1
General protein information
Preferred Names
ADP/ATP translocase 1
ADP/ATP translocase 1
ADP,ATP carrier protein 1
solute carrier family 25 member 4
heart/skeletal muscle ATP/ADP translocator
ADP,ATP carrier protein, heart/skeletal muscle
adenine nucleotide translocator 1 (skeletal muscle)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013].

MIM: 103220

Progressive external ophthalmoplegia with mitochondrial DNA

mRNA Protein Product Sequence Price Select
NM_001151, 258547122 NP_001142, 55749577 ADP/ATP translocase 1 ORF Sequence $199.00
hsa04020Calcium signaling pathway
hsa05016Huntington's disease
hsa05012Parkinson's disease
hsa05166HTLV-I infection
hsa04022cGMP-PKG signaling pathway
WP111Electron Transport Chain
WP706SIDS Susceptibility Pathways
WP2267Synaptic Vesicle Pathway
REACT_18325Regulation of insulin secretion
REACT_6185HIV Infection
REACT_6757Interactions of Vpr with host cellular proteins
REACT_6288Host Interactions of HIV factors
REACT_1505Integration of energy metabolism
REACT_8016Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
REACT_17015Metabolism of proteins
REACT_118595Mitochondrial protein import
Homo sapiens (human)SLC25A4NP_001142.2
Pan troglodytes (chimpanzee)SLC25A4XP_517556.3
Macaca mulatta (Rhesus monkey)SLC25A4XP_001084544.1
Canis lupus familiaris (dog)SLC25A4XP_532844.2
Bos taurus (cattle)SLC25A4NP_777083.1
Mus musculus (house mouse)Slc25a4NP_031476.3
Rattus norvegicus (Norway rat)Slc25a4NP_445967.1
Gallus gallus (chicken)SLC25A4NP_001006443.1
Danio rerio (zebrafish)slc25a4NP_999867.1
Drosophila melanogaster (fruit fly)sesBNP_727448.1
Xenopus (Silurana) tropicalis (western clawed frog)slc25a4NP_988909.1
GO:0000002mitochondrial genome maintenanceTAS
GO:0006091generation of precursor metabolites and energyTAS
GO:0006112energy reserve metabolic processTAS
GO:0008637apoptotic mitochondrial changesIEA
GO:0015853adenine transportTAS
GO:0016032viral processTAS
GO:0044281small molecule metabolic processTAS
GO:0050796regulation of insulin secretionTAS
GO:0055085transmembrane transportIEA
GO:0060546negative regulation of necroptotic processIMP
GO:0005743mitochondrial inner membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0005515protein bindingIPI
GO:0015207adenine transmembrane transporter activityTAS
GeneCards SLC25A4
UniProt P12235
Vega OTTHUMG00000134299
MIM 103220
Ensembl ENSG00000151729
HGNC 10990
HPRD 00058

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC25A4 gene?

The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). ANT1 functions in mitochondria, which are structures within cells that convert the energy from food into a form that cells can use. This process, called oxidative phosphorylation, converts adenosine diphosphate (ADP) into adenosine triphosphate (ATP), the cell's main energy source. ANT1 forms a channel in the mitochondrion's inner membrane. This channel allows ADP into the mitochondrion and ATP out of the mitochondrion to be used as energy for the cell. ANT1 may also be a part of another structure in the inner membrane called the mitochondrial permeability transition pore. This structure allows various molecules to pass into the mitochondrion and is thought to play a role in the self-destruction (apoptosis) of the cell.


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