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SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22413 NM_001151 Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22413C NM_001151 Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (SLC25A4), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol SLC25A4
Entrez Gene ID 291
Full Name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Synonyms 1, AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, T1
General protein information
Preferred Names
ADP/ATP translocase 1
Names
ADP/ATP translocase 1
ANT 1
ADP,ATP carrier protein 1
solute carrier family 25 member 4
heart/skeletal muscle ATP/ADP translocator
ADP,ATP carrier protein, heart/skeletal muscle
adenine nucleotide translocator 1 (skeletal muscle)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q35

Summary This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013].
Disorder

MIM: 103220

Progressive external ophthalmoplegia with mitochondrial DNA

mRNA Protein Product Sequence Price Select
NM_001151, 258547122 NP_001142, 55749577 ADP/ATP translocase 1 ORF Sequence $199.00
KEGG
hsa04020Calcium signaling pathway
hsa05016Huntington's disease
hsa05012Parkinson's disease
hsa05166HTLV-I infection
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP111Electron Transport Chain
WP706SIDS Susceptibility Pathways
WP2267Synaptic Vesicle Pathway
Reactome
REACT_18325Regulation of insulin secretion
REACT_6185HIV Infection
REACT_6757Interactions of Vpr with host cellular proteins
REACT_6288Host Interactions of HIV factors
REACT_1505Integration of energy metabolism
REACT_8016Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
REACT_17015Metabolism of proteins
REACT_111217Metabolism
REACT_116125Disease
REACT_118595Mitochondrial protein import
Homo sapiens (human)SLC25A4NP_001142.2
Pan troglodytes (chimpanzee)SLC25A4XP_517556.3
Macaca mulatta (Rhesus monkey)SLC25A4XP_001084544.1
Canis lupus familiaris (dog)SLC25A4XP_532844.2
Bos taurus (cattle)SLC25A4NP_777083.1
Mus musculus (house mouse)Slc25a4NP_031476.3
Rattus norvegicus (Norway rat)Slc25a4NP_445967.1
Gallus gallus (chicken)SLC25A4NP_001006443.1
Danio rerio (zebrafish)slc25a4NP_999867.1
Drosophila melanogaster (fruit fly)sesBNP_727448.1
Xenopus (Silurana) tropicalis (western clawed frog)slc25a4NP_988909.1
Process
IDNameEvidence
GO:0000002mitochondrial genome maintenanceTAS
GO:0006091generation of precursor metabolites and energyTAS
GO:0006112energy reserve metabolic processTAS
GO:0006810transportTAS
GO:0008637apoptotic mitochondrial changesIEA
GO:0015853adenine transportTAS
GO:0016032viral processTAS
GO:0044281small molecule metabolic processTAS
GO:0050796regulation of insulin secretionTAS
GO:0055085transmembrane transportIEA
GO:0060546negative regulation of necroptotic processIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005739mitochondrionIDA
GO:0005743mitochondrial inner membraneTAS
GO:0005887integral component of plasma membraneTAS
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0015207adenine transmembrane transporter activityTAS
GeneCards SLC25A4
UniProt P12235
Vega OTTHUMG00000134299
MIM 103220
Ensembl ENSG00000151729
HGNC 10990
HPRD 00058

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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