Ptgs2 prostaglandin-endoperoxide synthase 2 [Rattus norvegicus (Norway rat)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	Ptgs2
Entrez Gene ID	29527
Full Name	prostaglandin-endoperoxide synthase 2
Synonyms	COX-2, Cox2
Gene Type	protein-coding
Organism	Rattus norvegicus (Norway rat)
Genome	Chromosome:13 Map Location:13q21
Summary	catalyzes the conversion of arachidonic acid products to prostaglandin; may play a role in response to endotoxic shock; may a role in long term potentiation [RGD].
Disorder	MIM:

mRNA	NM_017232, 148747269
Protein	NP_058928, 148747270
Product	prostaglandin G/H synthase 2
RefSeq Status	PROVISIONAL

KEGG

rno05200	Pathways in cancer
rno01100	Metabolic pathways
rno04370	VEGF signaling pathway
rno00590	Arachidonic acid metabolism
rno05222	Small cell lung cancer
rno05140	Leishmaniasis

WikiPathways

WP293	Eicosanoid Synthesis
WP303	Prostaglandin Synthesis and Regulation

Reactome

1235498	Phase 1 - Functionalization of compounds
1235786	COX reactions
1235486	Metabolism of lipids and lipoproteins
1235456	Biological oxidations
1235625	Prostanoid metabolism

Homo sapiens (human)	PTGS2	NP_000954.1
Pan troglodytes (chimpanzee)	PTGS2	XP_524999.2
Canis lupus familiaris (dog)	PTGS2	NP_001003354.1
Bos taurus (cattle)	PTGS2	NP_776870.1
Mus musculus (house mouse)	Ptgs2	NP_035328.2
Rattus norvegicus (Norway rat)	Ptgs2	NP_058928.2
Gallus gallus (chicken)	PTGS2	XP_422297.1
Danio rerio (zebrafish)	ptgs2b	NP_001020675.1

Process

ID	Name	Evidence
GO:0001516	prostaglandin biosynthetic process	IMP
GO:0001516	prostaglandin biosynthetic process	TAS
GO:0006633	fatty acid biosynthetic process	IEA
GO:0006954	inflammatory response	IMP
GO:0006979	response to oxidative stress	IEA
GO:0007566	embryo implantation	IMP
GO:0007613	memory	IMP
GO:0008217	regulation of blood pressure	ISO
GO:0008217	regulation of blood pressure	ISS
GO:0008284	positive regulation of cell proliferation	TAS
GO:0008285	negative regulation of cell proliferation	IDA
GO:0009750	response to fructose stimulus	IEP
GO:0010033	response to organic substance	IEP
GO:0010042	response to manganese ion	IEP
GO:0010243	response to organic nitrogen	IEP
GO:0010575	positive regulation vascular endothelial growth factor production	IMP
GO:0014070	response to organic cyclic compound	IEP
GO:0019371	cyclooxygenase pathway	IEA
GO:0019371	cyclooxygenase pathway	ISO
GO:0030282	bone mineralization	IMP
GO:0030728	ovulation	IMP
GO:0031622	positive regulation of fever generation	IDA
GO:0031622	positive regulation of fever generation	ISO
GO:0031915	positive regulation of synaptic plasticity	IMP
GO:0032227	negative regulation of synaptic transmission, dopaminergic	IMP
GO:0032355	response to estradiol stimulus	IEP
GO:0032496	response to lipopolysaccharide	IMP
GO:0033280	response to vitamin D	IEP
GO:0034097	response to cytokine stimulus	IMP
GO:0042127	regulation of cell proliferation	ISO
GO:0042493	response to drug	IEP
GO:0042640	anagen	IEA
GO:0042640	anagen	ISO
GO:0043065	positive regulation of apoptosis	IMP
GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP
GO:0045907	positive regulation of vasoconstriction	IMP
GO:0045987	positive regulation of smooth muscle contraction	IMP
GO:0046697	decidualization	IMP
GO:0048661	positive regulation of smooth muscle cell proliferation	IMP
GO:0050873	brown fat cell differentiation	ISO
GO:0051384	response to glucocorticoid stimulus	IEP
GO:0051726	regulation of cell cycle	IEP
GO:0051926	negative regulation of calcium ion transport	IMP
GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP
GO:0071636	positive regulation of transforming growth factor-beta production	IMP
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IMP
GO:0090271	positive regulation of fibroblast growth factor production	IMP
GO:0090336	positive regulation of brown fat cell differentiation	IEA
GO:0090336	positive regulation of brown fat cell differentiation	ISO
GO:0090362	positive regulation of platelet-derived growth factor production	IMP

Component

ID	Name	Evidence
GO:0005634	nucleus	ISO
GO:0005634	nucleus	ISS
GO:0005635	nuclear envelope	TAS
GO:0005737	cytoplasm	IDA
GO:0005737	cytoplasm	ISO
GO:0005737	cytoplasm	ISS
GO:0005783	endoplasmic reticulum	TAS
GO:0005788	endoplasmic reticulum lumen	ISO
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005792	microsome	IEA
GO:0005901	caveola	IDA
GO:0016020	membrane	IEA
GO:0043005	neuron projection	IEA
GO:0043005	neuron projection	ISO
GO:0043234	protein complex	IDA

Function

ID	Name	Evidence
GO:0004601	peroxidase activity	IEA
GO:0004601	peroxidase activity	ISO
GO:0004666	prostaglandin-endoperoxide synthase activity	ISO
GO:0004666	prostaglandin-endoperoxide synthase activity	TAS
GO:0005515	protein binding	IPI
GO:0008289	lipid binding	IMP
GO:0016491	oxidoreductase activity	IEA
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA
GO:0019899	enzyme binding	IEA
GO:0019899	enzyme binding	ISO
GO:0020037	heme binding	IEA
GO:0046872	metal ion binding	IEA

GeneCards	Ptgs2
UniProt	P35355
RGD	620349
Ensembl	ENSRNOG00000002525

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RefSeq Accession	Definition	Sequence	Price	Select
NM_017232	Rattus norvegicus prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA.	Full Length	$526.35
NM_017232		ORF Sequence	$526.35