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HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18260 NM_001037811 Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18855 NM_004493 Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18260C NM_001037811 Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu18855C NM_004493 Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol HSD17B10
Entrez Gene ID 3028
Full Name hydroxysteroid (17-beta) dehydrogenase 10
Synonyms 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
General protein information
Preferred Names
3-hydroxyacyl-CoA dehydrogenase type-2
Names
3-hydroxyacyl-CoA dehydrogenase type-2
mitochondrial RNase P subunit 2
AB-binding alcohol dehydrogenase
mitochondrial ribonuclease P protein 2
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
short chain type dehydrogenase/reductase XH98G2
amyloid-beta peptide binding alcohol dehydrogenase
short chain L-3-hydroxyacyl-CoA dehydrogenase type 2
short chain dehydrogenase/reductase family 5C, member 1
endoplasmic reticulum-associated amyloid beta-peptide-binding protein
NP_001032900.1
NP_004484.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.2

Summary This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 300256

17-beta-hydroxysteroid dehydrogenase X deficiency, 300438 (3);

mRNA Protein Product Sequence Price Select
NM_001037811, 91823617 NP_001032900, 83715985 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 2 ORF Sequence $199.00
NM_004493, 91823611 NP_004484, 4758504 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1 ORF Sequence $199.00
KEGG
hsa00280Valine, leucine and isoleucine degradation
hsa05010Alzheimer's disease
WikiPathways
WP465Tryptophan metabolism
WP2059Alzheimers Disease
BIOCYC
META_FAO-PWYfatty acid beta-oxidation I
HUMAN_ILEUDEG-PWYisoleucine degradation I
HUMAN_FAO-PWYfatty acid beta-oxidation I
Reactome
REACT_13Metabolism of amino acids and derivatives
REACT_197Branched-chain amino acid catabolism
REACT_111217Metabolism
Homo sapiens (human)HSD17B10NP_004484.1
Pan troglodytes (chimpanzee)HSD17B10XP_003317521.1
Macaca mulatta (Rhesus monkey)HSD17B10XP_001087982.1
Canis lupus familiaris (dog)HSD17B10XP_538051.2
Bos taurus (cattle)HSD17B10NP_776759.1
Mus musculus (house mouse)Hsd17b10NP_058043.3
Rattus norvegicus (Norway rat)Hsd17b10NP_113870.1
Danio rerio (zebrafish)hsd17b10NP_001006098.1
Drosophila melanogaster (fruit fly)scuNP_523396.1
Caenorhabditis elegansard-1NP_502083.1
Xenopus (Silurana) tropicalis (western clawed frog)hsd17b10NP_001016511.1
Process
IDNameEvidence
GO:0006629lipid metabolic processTAS
GO:0008033tRNA processingIEA
GO:0009083branched-chain amino acid catabolic processTAS
GO:0034641cellular nitrogen compound metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005737cytoplasmTAS
GO:0005739mitochondrionISS
GO:0005743mitochondrial inner membraneIEA
GO:0005759mitochondrial matrixTAS
GO:0005783endoplasmic reticulumIEA
GO:0005886plasma membraneTAS
Function
IDNameEvidence
GO:00038573-hydroxyacyl-CoA dehydrogenase activityEXP
GO:0005515protein bindingIPI
GO:0008709cholate 7-alpha-dehydrogenase activityTAS
GO:0030283testosterone dehydrogenase [NAD(P)] activityIEA
GO:0044822poly(A) RNA bindingIDA
GO:00470153-hydroxy-2-methylbutyryl-CoA dehydrogenase activityIEA
GeneCards HSD17B10
UniProt Q99714
Vega OTTHUMG00000021612
MIM 300256
Ensembl ENSG00000072506
HGNC 4800
HPRD 02223

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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