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Sequence in raw or FASTA format:

Database:

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ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [Danio rerio (zebrafish)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
XM_692154 PREDICTED: Danio rerio neurotrophic tyrosine kinase, receptor, type 1 (ntrk1), mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol ntrk1
Entrez Gene ID 30546
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms trk, trka
General protein information
Preferred Names
high affinity nerve growth factor receptor
Names
high affinity nerve growth factor receptor
tyrosine kinase receptor A
Gene Type protein-coding
Organism Danio rerio (zebrafish)
Genome

16

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
XM_692154, 528504972 XP_697246, 528504973 high affinity nerve growth factor receptor ORF Sequence $750.00
KEGG
dre04210Apoptosis
dre04010MAPK signaling pathway
dre04144Endocytosis
WikiPathways
WP1337MAPK signaling pathway
Reactome
5857564Signalling by NGF
5857550Signal Transduction
5857563NGF signalling via TRKA from the plasma membrane
5857919TRKA activation by NGF
5858104Signalling to STAT3
5858022NGF-independant TRKA activation
5857603Signalling to RAS
5857693Signalling to p38 via RIT and RIN
5857689Frs2-mediated activation
5857691ARMS-mediated activation
5858100PI3K/AKT activation
5857690Prolonged ERK activation events
5857604Signalling to ERKs
5857562PLC-gamma1 signalling
5857920Activation of TRKA receptors
5858015Retrograde neurotrophin signalling
Homo sapiens (human)NTRK1NP_002520.2
Pan troglodytes (chimpanzee)NTRK1XP_003308563.1
Macaca mulatta (Rhesus monkey)NTRK1XP_001114243.2
Canis lupus familiaris (dog)NTRK1XP_851619.3
Bos taurus (cattle)NTRK1XP_002686012.2
Mus musculus (house mouse)Ntrk1NP_001028296.1
Rattus norvegicus (Norway rat)Ntrk1NP_067600.1
Gallus gallus (chicken)NTRK1NP_990709.1
Danio rerio (zebrafish)ntrk1XP_697246.5
Xenopus (Silurana) tropicalis (western clawed frog)ntrk1XP_002939035.1
Process
IDNameEvidence
GO:0006468protein phosphorylationIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA
GO:0016310phosphorylationIEA
Component
IDNameEvidence
GO:0005887integral component of plasma membraneIEA
GO:0016020membraneIEA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0004672protein kinase activityIEA
GO:0004713protein tyrosine kinase activityIEA
GO:0004714transmembrane receptor protein tyrosine kinase activityIEA
GO:0005030neurotrophin receptor activityIEA
GO:0005524ATP bindingIEA
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsIEA
GeneCards ntrk1
Vega OTTDARG00000027779
Ensembl ENSDARG00000004586
ZFIN ZDB

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NTRK1 gene?

The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons). The NTRK1 protein is found on the surface of cells, particularly sensory neurons. It acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. This process is called phosphorylation. The NTRK1 protein is turned on (activated) when another protein called nerve growth factor beta (NGFβ) attaches (binds) to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). Then, the activated NTRK1 protein phosphorylates other proteins; this process is needed to transmit signals for cell growth and survival.

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