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HLA-C major histocompatibility complex, class I, C [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001243042 Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_002117 Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol HLA-C
Entrez Gene ID 3107
Full Name major histocompatibility complex, class I, C
Synonyms D6S204, FLJ27082, HLA-Cw, HLA-JY3, HLC-C, PSORS1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].
Disorder

MIM: 142840

{Psoriasis susceptibility 1}, 177900 (3); {HIV-1

mRNA Protein Product Sequence Price Select
NM_001243042, 339882740 NP_001229971, 339882741 HLA class I histocompatibility antigen, Cw-1 alpha chain precursor ORF Sequence $400.00
NM_002117, 339882742 NP_002108, 52630342 HLA class I histocompatibility antigen, Cw-1 alpha chain precursor ORF Sequence $400.00
KEGG
hsa05169Epstein-Barr virus infection
hsa04650Natural killer cell mediated cytotoxicity
hsa05203Viral carcinogenesis
hsa04940Type I diabetes mellitus
hsa04514Cell adhesion molecules (CAMs)
hsa05332Graft-versus-host disease
hsa05168Herpes simplex infection
hsa04144Endocytosis
hsa04612Antigen processing and presentation
hsa05416Viral myocarditis
hsa05320Autoimmune thyroid disease
hsa05166HTLV-I infection
hsa05330Allograft rejection
hsa04145Phagosome
WikiPathways
WP183Proteasome Degradation
Reactome
REACT_25229Interferon Signaling
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_25162Interferon alpha/beta signaling
REACT_111178ER-Phagosome pathway
REACT_75790Cytokine Signaling in Immune system
REACT_111119Antigen processing-Cross presentation
REACT_75774Adaptive Immune System
REACT_25078Interferon gamma signaling
REACT_111168Endosomal/Vacuolar pathway
REACT_11152Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_147694DAP12 interactions
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Homo sapiens (human)HLA-CNP_002108.4
Pan troglodytes (chimpanzee)PATR-CNP_001012441.2
Macaca mulatta (Rhesus monkey)LOC694372XP_001082170.2
GeneCards HLA-C
PDB 3BZF
UniProt O19617, Q6R739, Q95HC2, P10321
MIM 142840
Ensembl ENSG00000204525
HGNC 4933
HPRD 00829

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
HLA class I histocompatibility antigen, Cw-1 alpha chain
Names
HLA class I histocompatibility antigen, Cw-1 alpha chain
MHC class I antigen heavy chain HLA-C
human leukocyte antigen-C alpha chain
major histocompatibility antigen HLA-C
HLA class I histocompatibility antigen, C alpha chain

Interactant



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