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HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001198858 Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol HLA-DQB2
Entrez Gene ID 3120
Full Name major histocompatibility complex, class II, DQ beta 2
Synonyms HLA-DQB1, HLA-DXB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21

Summary HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001198858, 311893320 NP_001185787, 311893321 HLA class II histocompatibility antigen, DQ beta 2 chain precursor ORF Sequence $250.00
Reactome
REACT_19344Costimulation by the CD28 family
REACT_25229Interferon Signaling
REACT_75774Adaptive Immune System
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_121399MHC class II antigen presentation
REACT_12526TCR signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_6900Immune System
REACT_19324PD-1 signaling
REACT_25078Interferon gamma signaling
REACT_75790Cytokine Signaling in Immune system
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
GeneCards HLA-DQB2
UniProt P05538
HGNC 4945
HPRD 09984

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
HLA class II histocompatibility antigen, DQ beta 2 chain
Names
HLA class II histocompatibility antigen, DQ beta 2 chain
MHC class II antigen DQB2
major histocompatibility complex, class II, DQ beta 1
HLA class II histocompatibility antigen, DX beta chain
DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))

Interactant



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