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Sequence in raw or FASTA format:

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HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20438 NM_001198858 Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40289 XM_005249051 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54618 XM_005274855 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54618 XM_005272807 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40289 XM_005275546 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu20438C NM_001198858 Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), mRNA. Customized vector On-demand 7-9 $209.00
OHu40289C XM_005249051 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu54618C XM_005274855 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu54618C XM_005272807 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu40289C XM_005275546 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol HLA-DQB2
Entrez Gene ID 3120
Full Name major histocompatibility complex, class II, DQ beta 2
Synonyms HLA-DQB1, HLA-DXB
General protein information
Preferred Names
HLA class II histocompatibility antigen, DQ beta 2 chain
Names
HLA class II histocompatibility antigen, DQ beta 2 chain
MHC class II antigen DQB2
major histocompatibility complex, class II, DQ beta 1
HLA class II histocompatibility antigen, DX beta chain
DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21

Summary HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010].
Disorder

MIM: 615161

mRNA Protein Product Sequence Price Select
NM_001198858, 311893320 NP_001185787, 311893321 HLA class II histocompatibility antigen, DQ beta 2 chain precursor ORF Sequence $250.00
XM_005249051, 578811645 XP_005249108, 530381882 HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 ORF Sequence $300.00
XM_005272807, 578840834 XP_005272864, 530427989 HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 ORF Sequence $300.00
XM_005274855, 578839601 XP_005274912, 530427775 HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 ORF Sequence $300.00
XM_005275546, 578842312 XP_005275603, 530429580 HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 ORF Sequence $300.00
Reactome
REACT_19344Costimulation by the CD28 family
REACT_19324PD-1 signaling
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_121399MHC class II antigen presentation
Process
IDNameEvidence
GO:0006955immune responseNAS
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0031295T cell costimulationTAS
GO:0050852T cell receptor signaling pathwayTAS
GO:0060333interferon-gamma-mediated signaling pathwayTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneTAS
GO:0005886plasma membraneTAS
GO:0010008endosome membraneIEA
GO:0012507ER to Golgi transport vesicle membraneTAS
GO:0030658transport vesicle membraneTAS
GO:0030666endocytic vesicle membraneTAS
GO:0030669clathrin-coated endocytic vesicle membraneTAS
GO:0032588trans-Golgi network membraneTAS
GO:0042613MHC class II protein complexNAS
GO:0071556integral component of lumenal side of endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0032395MHC class II receptor activityNAS
GeneCards HLA-DQB2
UniProt A2ADX3, P05538
Vega OTTHUMG00000031125
MIM 615161
Ensembl ENSG00000232629
HGNC 4945
HPRD 09984

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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