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HNF4A hepatocyte nuclear factor 4, alpha [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25120 NM_178849 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25127 NM_178850 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25149 NM_175914 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25191 NM_001258355 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 7, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25204 NM_001287183 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 9, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25247 NM_001030003 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25252 NM_001287182 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 8, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25281 NM_001287184 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 10, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25290 NM_000457 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25302 NM_001030004 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu52995 XM_005260407 PREDICTED: Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25120C NM_178849 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu25127C NM_178850 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu25149C NM_175914 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu25191C NM_001258355 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 7, mRNA. Customized vector On-demand 7-9 $269.00
OHu25204C NM_001287183 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 9, mRNA. Customized vector On-demand 7-9 $269.00
OHu25247C NM_001030003 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu25252C NM_001287182 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 8, mRNA. Customized vector On-demand 7-9 $269.00
OHu25281C NM_001287184 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 10, mRNA. Customized vector On-demand 7-9 $269.00
OHu25290C NM_000457 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu25302C NM_001030004 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 6, mRNA. Customized vector On-demand 7-9 $269.00
OHu52995C XM_005260407 PREDICTED: Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol HNF4A
Entrez Gene ID 3172
Full Name hepatocyte nuclear factor 4, alpha
Synonyms HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14
General protein information
Preferred Names
hepatocyte nuclear factor 4-alpha
Names
hepatocyte nuclear factor 4-alpha
TCF-14
HNF4alpha10/11/12
transcription factor 14
transcription factor HNF-4
hepatic nuclear factor 4 alpha
nuclear receptor subfamily 2 group A member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.12

Summary The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012].
Disorder

MIM: 600281

MODY, type I, 125850 (3); {Diabetes mellitus, noninsulin-dependent},

mRNA Protein Product Sequence Price Select
NM_000457, 385298689 NP_000448, 31077205 hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 ORF Sequence $550.00
NM_001030003, 385298686 NP_001025174, 71725341 hepatocyte nuclear factor 4-alpha isoform HNF4alpha7 ORF Sequence $550.00
NM_001030004, 385298687 NP_001025175, 71725336 hepatocyte nuclear factor 4-alpha isoform HNF4alpha9 ORF Sequence $400.00
NM_001258355, 385298693 NP_001245284, 385298694 hepatocyte nuclear factor 4-alpha isoform HNF4alpha4 ORF Sequence $550.00
NM_001287182, 563407069 NP_001274111, 563407070 hepatocyte nuclear factor 4-alpha isoform HNF4alpha10 ORF Sequence $550.00
NM_001287183, 563407071 NP_001274112, 563407072 hepatocyte nuclear factor 4-alpha isoform HNF4alpha11 ORF Sequence $550.00
NM_001287184, 563407073 NP_001274113, 563407074 hepatocyte nuclear factor 4-alpha isoform HNF4alpha12 ORF Sequence $400.00
NM_175914, 385298688 NP_787110, 71725339 hepatocyte nuclear factor 4-alpha isoform HNF4alpha8 ORF Sequence $550.00
NM_178849, 385298690 NP_849180, 31077207 hepatocyte nuclear factor 4-alpha isoform HNF4alpha1 ORF Sequence $550.00
NM_178850, 385298691 NP_849181, 31077209 hepatocyte nuclear factor 4-alpha isoform HNF4alpha3 ORF Sequence $550.00
XM_005260407, 530418096 XP_005260464, 530418097 hepatocyte nuclear factor 4-alpha isoform X1 ORF Sequence $550.00
KEGG
hsa04950Maturity onset diabetes of the young
hsa04152AMPK signaling pathway
WikiPathways
WP366TGF-beta Receptor Signaling Pathway
WP170Nuclear Receptors
WP1403AMPK signaling
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
hif1_tfpathwayHIF-1-alpha transcription factor network
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_15525Nuclear Receptor transcription pathway
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_111045Developmental Biology
Homo sapiens (human)HNF4ANP_000448.3
Pan troglodytes (chimpanzee)HNF4AXP_514664.4
Macaca mulatta (Rhesus monkey)HNF4AXP_001110097.2
Canis lupus familiaris (dog)HNF4AXP_852731.1
Bos taurus (cattle)HNF4ANP_001015557.1
Mus musculus (house mouse)Hnf4aNP_032287.2
Rattus norvegicus (Norway rat)Hnf4aNP_071516.2
Gallus gallus (chicken)HNF4ANP_001026026.1
Danio rerio (zebrafish)hnf4aNP_919349.1
Xenopus (Silurana) tropicalis (western clawed frog)hnf4aXP_002933229.2
Process
IDNameEvidence
GO:0006357regulation of transcription from RNA polymerase II promoterIDA
GO:0006357regulation of transcription from RNA polymerase II promoterIMP
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006591ornithine metabolic processIMP
GO:0006629lipid metabolic processIEA
GO:0006805xenobiotic metabolic processIMP
GO:0007548sex differentiationIEA
GO:0007596blood coagulationIDA
GO:0008285negative regulation of cell proliferationIMP
GO:0009749response to glucoseISS
GO:0010467gene expressionTAS
GO:0010470regulation of gastrulationIEA
GO:0019216regulation of lipid metabolic processIDA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030308negative regulation of cell growthIMP
GO:0030522intracellular receptor signaling pathwayIEA
GO:0031018endocrine pancreas developmentTAS
GO:0042593glucose homeostasisISS
GO:0043401steroid hormone mediated signaling pathwayIEA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0050796regulation of insulin secretionISS
GO:0055088lipid homeostasisIMP
GO:0055091phospholipid homeostasisISS
GO:0060395SMAD protein signal transductionIEA
GO:0060398regulation of growth hormone receptor signaling pathwayNAS
GO:0070328triglyceride homeostasisISS
GO:2000189positive regulation of cholesterol homeostasisISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISS
GO:0001102RNA polymerase II activating transcription factor bindingISS
GO:0003677DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA
GO:0003707steroid hormone receptor activityIEA
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEA
GO:0005102receptor bindingIDA
GO:0005504fatty acid bindingIDA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0042803protein homodimerization activityIDA
GO:0043565sequence-specific DNA bindingIEA
GO:0044212transcription regulatory region DNA bindingIDA
GeneCards HNF4A
UniProt P41235, F1D8T0, F1D8S2, B9VVT8, F1D8T1
Vega OTTHUMG00000032531
MIM 600281
Ensembl ENSG00000101076
HGNC 5024
HPRD 02612

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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