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HNF4A hepatocyte nuclear factor 4, alpha [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000457 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 2, mRNA. ORF Sequence $413.25
Peptide Services
Antibody Services
Protein Services
NM_001030003 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 5, mRNA. ORF Sequence $385.41
Peptide Services
Antibody Services
Protein Services
NM_001030004 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 6, mRNA. ORF Sequence $344.52
Peptide Services
Antibody Services
Protein Services
NM_001258355 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 7, mRNA. ORF Sequence $407.16
Peptide Services
Antibody Services
Protein Services
NM_175914 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 4, mRNA. ORF Sequence $394.11
Peptide Services
Antibody Services
Protein Services
NM_178849 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 1, mRNA. ORF Sequence $404.55
Peptide Services
Antibody Services
Protein Services
NM_178850 Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 3, mRNA. ORF Sequence $363.66
Peptide Services
Antibody Services
Protein Services


Gene Symbol HNF4A
Entrez Gene ID 3172
Full Name hepatocyte nuclear factor 4, alpha
Synonyms FLJ39654, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.12

Summary The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012].
Disorder

MIM: 600281

MODY, type I, 125850 (3); {Diabetes mellitus, noninsulin-dependent},

mRNA Protein Product Sequence Price Select
NM_000457, 385298689 NP_000448, 31077205 hepatocyte nuclear factor 4-alpha isoform b Full Length $1657.95
ORF Sequence $413.25
NM_001030003, 385298686 NP_001025174, 71725341 hepatocyte nuclear factor 4-alpha isoform e Full Length $1584.80
ORF Sequence $385.41
NM_001030004, 385298687 NP_001025175, 71725336 hepatocyte nuclear factor 4-alpha isoform f Full Length $420.21
ORF Sequence $344.52
NM_001258355, 385298693 NP_001245284, 385298694 hepatocyte nuclear factor 4-alpha isoform g Full Length $1689.80
ORF Sequence $407.16
NM_175914, 385298688 NP_787110, 71725339 hepatocyte nuclear factor 4-alpha isoform d Full Length $1595.30
ORF Sequence $394.11
NM_178849, 385298690 NP_849180, 31077207 hepatocyte nuclear factor 4-alpha isoform a Full Length $1647.45
ORF Sequence $404.55
NM_178850, 385298691 NP_849181, 31077209 hepatocyte nuclear factor 4-alpha isoform c Full Length $472.12
ORF Sequence $363.66
KEGG
hsa04950Maturity onset diabetes of the young
Pathway Interaction Database
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
hif1_tfpathwayHIF-1-alpha transcription factor network
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
WikiPathways
WP2256Integrated Pancreatic Cancer Pathway
WP170Nuclear Receptors
WP1403AMPK signaling
WP2377Integrated Pancreatic Cancer Pathway
WP366TGF-beta Receptor Signaling Pathway
Reactome
REACT_13698Regulation of beta-cell development
REACT_15525Nuclear Receptor transcription pathway
REACT_13819Regulation of gene expression in beta cells
REACT_71Gene Expression
REACT_111045Developmental Biology
REACT_12627Generic Transcription Pathway
Homo sapiens (human)HNF4ANP_000448.3
Pan troglodytes (chimpanzee)HNF4AXP_514664.4
Macaca mulatta (Rhesus monkey)HNF4AXP_001110097.2
Canis lupus familiaris (dog)HNF4AXP_543008.2
Bos taurus (cattle)HNF4ANP_001015557.1
Mus musculus (house mouse)Hnf4aNP_032287.2
Rattus norvegicus (Norway rat)Hnf4aNP_071516.1
Gallus gallus (chicken)HNF4ANP_001026026.1
Danio rerio (zebrafish)hnf4aNP_919349.1
Caenorhabditis elegansnhr-69NP_492615.2
GeneCards HNF4A
PDB 3FS1, 1PZL, 3CBB
UniProt P41235, F1D8T0, F1D8S2, F1D8T1
MIM 600281
Ensembl ENSG00000101076
HGNC 5024
HPRD 02612

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
hepatocyte nuclear factor 4-alpha
Names
hepatocyte nuclear factor 4-alpha
TCF-14
HNF4alpha10/11/12
transcription factor 14
transcription factor HNF-4
hepatic nuclear factor 4 alpha
nuclear receptor subfamily 2 group A member 1

Interactant

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