Sequence in raw or FASTA format:
HIST2H2AB histone cluster 2, H2ab [Homo sapiens (human)]
| Gene Symbol | HIST2H2AB |
| Entrez Gene ID | 317772 |
| Full Name | histone cluster 2, H2ab |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q21 |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_175065, 29171728 |
| Protein | NP_778235, 28195394 |
| Product | histone H2A type 2-B |
| RefSeq Status | REVIEWED |
| hsa05322 | Systemic lupus erythematosus |
| Homo sapiens (human) | HIST2H2AB | NP_778235.1 |
| Pan troglodytes (chimpanzee) | LOC746557 | XP_001166488.1 |
| Canis lupus familiaris (dog) | LOC483175 | XP_540293.2 |
| Bos taurus (cattle) | HIST2H2AB | XP_871733.2 |
| Mus musculus (house mouse) | Hist2h2ab | NP_835585.3 |
| Rattus norvegicus (Norway rat) | Hist2h2ab | XP_001073270.1 |
| Danio rerio (zebrafish) | zgc:101846 | NP_001005967.1 |
| Danio rerio (zebrafish) | LOC100148591 | XP_001922365.1 |
| Danio rerio (zebrafish) | LOC565202 | XP_693579.2 |
| Danio rerio (zebrafish) | LOC100332885 | XP_002666967.1 |
| Danio rerio (zebrafish) | LOC565417 | XP_693788.1 |
| Danio rerio (zebrafish) | LOC100000574 | XP_001334871.1 |
| Danio rerio (zebrafish) | LOC100001004 | XP_001335390.1 |
| Danio rerio (zebrafish) | LOC100151041 | XP_001920286.2 |
| Danio rerio (zebrafish) | LOC100000783 | XP_001335136.1 |
| Danio rerio (zebrafish) | LOC100334621 | XP_002666947.1 |
| Danio rerio (zebrafish) | LOC560309 | XP_688798.1 |
| Danio rerio (zebrafish) | zgc:110434 | NP_001019567.1 |
| Danio rerio (zebrafish) | LOC560527 | XP_689030.2 |
| Danio rerio (zebrafish) | LOC570115 | XP_698647.2 |
| Danio rerio (zebrafish) | LOC561187 | XP_689685.1 |
| Danio rerio (zebrafish) | LOC100334934 | XP_002666988.1 |
| Danio rerio (zebrafish) | LOC563177 | XP_691638.1 |
| Danio rerio (zebrafish) | zgc:114037 | NP_001026996.1 |
| Danio rerio (zebrafish) | LOC100006331 | XP_001345113.2 |
| Danio rerio (zebrafish) | LOC100004768 | XP_001338956.1 |
| Danio rerio (zebrafish) | LOC100333384 | XP_002666975.1 |
| Danio rerio (zebrafish) | zgc:173652 | NP_001096634.1 |
| Danio rerio (zebrafish) | LOC100333205 | XP_002666972.1 |
| Danio rerio (zebrafish) | LOC100004171 | XP_001336709.1 |
| Danio rerio (zebrafish) | LOC559220 | XP_687630.2 |
| Danio rerio (zebrafish) | LOC100004510 | XP_001337024.1 |
| Danio rerio (zebrafish) | zgc:195633 | NP_001136058.1 |
| Caenorhabditis elegans | his-3 | NP_507032.1 |
| Caenorhabditis elegans | his-68 | NP_492642.1 |
| Caenorhabditis elegans | his-43 | NP_496898.1 |
| Caenorhabditis elegans | his-61 | NP_501201.1 |
| Caenorhabditis elegans | his-7 | NP_505198.1 |
| Caenorhabditis elegans | his-47 | NP_502131.1 |
| Caenorhabditis elegans | his-21 | NP_505293.1 |
| Caenorhabditis elegans | his-57 | NP_502141.1 |
| Caenorhabditis elegans | his-65 | NP_502150.1 |
| Caenorhabditis elegans | his-51 | NP_505277.1 |
| Caenorhabditis elegans | his-53 | NP_505280.1 |
| Caenorhabditis elegans | his-12 | NP_496891.1 |
| Caenorhabditis elegans | his-16 | NP_496887.1 |
| Caenorhabditis elegans | his-30 | NP_501404.1 |
| Caenorhabditis elegans | his-33 | NP_501408.1 |
| Caenorhabditis elegans | his-19 | NP_505296.1 |
| Caenorhabditis elegans | his-35 | NP_505463.1 |
| Arabidopsis thaliana (thale cress) | HTA6 | NP_200795.1 |
| ID | Name | Evidence |
| GO:0006334 | nucleosome assembly | IEA |
Component
| ID | Name | Evidence |
| GO:0000786 | nucleosome | IEA |
| GO:0005634 | nucleus | IEA |
| GO:0005694 | chromosome | IEA |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | IEA |
| GeneCards | HIST2H2AB |
| UniProt | Q8IUE6 |
| Ensembl | ENSG00000184270 |
| HGNC | 20508 |
| HPRD | 13659 |
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