NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [Bos taurus (cattle)]
| Gene Symbol | NTRK1 |
| Entrez Gene ID | 353111 |
| Full Name | neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms | TRKA |
| Gene Type | protein-coding |
| Organism | Bos taurus (cattle) |
| Genome |
3 |
| Summary | |
| Disorder | MIM: |
| mRNA | XM_882395, 297465483 |
| Protein | XP_887488, 194665080 |
| Product | neurotrophic tyrosine kinase, receptor, type 1 isoform 3 |
| RefSeq Status | MODEL |
| mRNA | XM_613650, 297465484 |
| Protein | XP_613650, 194665082 |
| Product | neurotrophic tyrosine kinase, receptor, type 1 isoform 1 |
| RefSeq Status | MODEL |
| mRNA | XM_002685965, 297472546 |
| Protein | XP_002686011, 297472547 |
| Product | neurotrophic tyrosine kinase, receptor, type 1 isoform 1 |
| RefSeq Status | MODEL |
| mRNA | XM_002685966, 297472548 |
| Protein | XP_002686012, 297472549 |
| Product | neurotrophic tyrosine kinase, receptor, type 1 isoform 2 |
| RefSeq Status | MODEL |
| bta05216 | Thyroid cancer |
| bta04210 | Apoptosis |
| bta04144 | Endocytosis |
| bta04722 | Neurotrophin signaling pathway |
| bta04010 | MAPK signaling pathway |
| bta05200 | Pathways in cancer |
WikiPathways
| WP998 | MAPK signaling pathway |
Reactome
| 1163669 | PLC-gamma1 signalling |
| 1164165 | PI3K/AKT signalling |
| 1163785 | Prolonged ERK activation events |
| 1163779 | Signalling to p38 via RIT and RIN |
| 1163687 | Signalling to ERKs |
| 1164005 | Activation of TRKA receptors |
| 1163671 | Signalling by NGF |
| 1164004 | TRKA activation by NGF |
| 1163786 | ARMS-mediated activation |
| 1164074 | NGF-independant TRKA activation |
| 1163784 | Frs2-mediated activation |
| 1163670 | NGF signalling via TRKA from the plasma membrane |
| 1164177 | Signalling to STAT3 |
| 1163686 | Signalling to RAS |
| 1164069 | Retrograde neurotrophin signalling |
| Homo sapiens (human) | NTRK1 | NP_002520.2 |
| Pan troglodytes (chimpanzee) | NTRK1 | XP_001145942.1 |
| Canis lupus familiaris (dog) | NTRK1 | XP_547525.2 |
| Bos taurus (cattle) | NTRK1 | XP_613650.3 |
| Mus musculus (house mouse) | Ntrk1 | XP_283871.1 |
| Rattus norvegicus (Norway rat) | Ntrk1 | NP_067600.1 |
| Gallus gallus (chicken) | NTRK1 | NP_990709.1 |
| Danio rerio (zebrafish) | ntrk1 | XP_697246.4 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IEA |
| GO:0007399 | nervous system development | IEA |
| GO:0030183 | B cell differentiation | IEA |
| GO:0042490 | mechanoreceptor differentiation | IEA |
| GO:0043524 | negative regulation of neuron apoptosis | IEA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005887 | integral to plasma membrane | IEA |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA |
| GO:0005030 | neurotrophin receptor activity | IEA |
| GO:0005524 | ATP binding | IEA |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | IEA |
| GeneCards | NTRK1 |
| Ensembl | ENSBTAG00000003060 |
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