PADI6 peptidyl arginine deiminase, type VI [Homo sapiens (human)]
| Gene Symbol | PADI6 |
| Entrez Gene ID | 353238 |
| Full Name | peptidyl arginine deiminase, type VI |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36.13 |
| Summary | Peptidylarginine deiminases (PADs, EC 3.5.3.15), including PADI6, make up a family of posttranslational protein modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ions.[supplied by OMIM]. |
| Disorder | MIM: 610363 |
| mRNA | NM_207421, 117414157 |
| Protein | NP_997304, 117414158 |
| Product | protein-arginine deiminase type-6 |
| RefSeq Status | VALIDATED |
| META_PWY-4921 | protein citrullination |
| Homo sapiens (human) | PADI6 | NP_997304.3 |
| Pan troglodytes (chimpanzee) | PADI6 | XP_524564.2 |
| Canis lupus familiaris (dog) | PADI6 | XP_544538.2 |
| Bos taurus (cattle) | PADI6 | XP_609569.4 |
| Mus musculus (house mouse) | Padi6 | NP_694746.2 |
| Rattus norvegicus (Norway rat) | Padi6 | XP_233601.3 |
| ID | Name | Evidence |
| GO:0006464 | protein modification process | IEA |
| GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0045111 | intermediate filament cytoskeleton | IEA |
Function
| ID | Name | Evidence |
| GO:0004668 | protein-arginine deiminase activity | IEA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0016787 | hydrolase activity | IEA |
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