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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


IL2RA interleukin 2 receptor, alpha [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21222 NM_000417 Homo sapiens interleukin 2 receptor, alpha (IL2RA), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu43745 XM_005252446 PREDICTED: Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu21222C NM_000417 Homo sapiens interleukin 2 receptor, alpha (IL2RA), mRNA. Customized vector In-stock 5-7 $149.00
OHu43745C XM_005252446 PREDICTED: Homo sapiens interleukin 2 receptor, alpha (IL2RA), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

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Gene Symbol IL2RA
Entrez Gene ID 3559
Full Name interleukin 2 receptor, alpha
Synonyms CD25, IDDM10, IL2R, TCGFR
General protein information
Preferred Names
interleukin-2 receptor subunit alpha
Names
interleukin-2 receptor subunit alpha
p55
IL2-RA
IL-2-RA
TAC antigen
IL-2R subunit alpha
IL-2 receptor subunit alpha
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10p15-p14

Summary The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009].
Disorder

MIM: 147730

Interleukin-2 receptor, alpha chain, deficiency of, 606367 (3);

mRNA Protein Product Sequence Price Select
NM_000417, 269973860 NP_000408, 4557667 interleukin-2 receptor subunit alpha precursor ORF Sequence $199.00
XM_005252446, 530392147 XP_005252503, 530392148 interleukin-2 receptor subunit alpha isoform X1 ORF Sequence $250.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa04144Endocytosis
hsa05166HTLV-I infection
hsa05162Measles
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP453Inflammatory Response Pathway
WP49IL-2 Signaling pathway
WP2203TSLP Signaling Pathway
Pathway Interaction Database
tcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway
il2_pi3kpathwayIL2 signaling events mediated by PI3K
il12_stat4pathwayIL12 signaling mediated by STAT4
il2_1pathwayIL2-mediated signaling events
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
il12_2pathwayIL12-mediated signaling events
arf6_traffickingpathwayArf6 trafficking events
il2_stat5pathwayIL2 signaling events mediated by STAT5
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
Reactome
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_27283Interleukin-2 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
Homo sapiens (human)IL2RANP_000408.1
Pan troglodytes (chimpanzee)IL2RANP_001030597.1
Macaca mulatta (Rhesus monkey)IL2RANP_001028089.1
Canis lupus familiaris (dog)IL2RANP_001003211.1
Bos taurus (cattle)IL2RANP_776783.1
Mus musculus (house mouse)Il2raNP_032393.3
Rattus norvegicus (Norway rat)Il2raNP_037295.1
Process
IDNameEvidence
GO:0002437inflammatory response to antigenic stimulusIEA
GO:0006915apoptotic processTAS
GO:0006924activation-induced cell death of T cellsIEA
GO:0006955immune responseTAS
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007219Notch signaling pathwayIEA
GO:0008283cell proliferationTAS
GO:0038110interleukin-2-mediated signaling pathwayIEA
GO:0042104positive regulation of activated T cell proliferationIEA
GO:0042130negative regulation of T cell proliferationIEA
GO:0045582positive regulation of T cell differentiationIEA
GO:0046013regulation of T cell homeostatic proliferationIEA
GO:0050687negative regulation of defense response to virusIEA
GO:0050728negative regulation of inflammatory responseIEA
GO:0050777negative regulation of immune responseIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0009897external side of plasma membraneIEA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004911interleukin-2 receptor activityIEA
GO:0008144drug bindingIEA
GO:0019976interleukin-2 bindingIEA
GeneCards IL2RA
PDB 3IU3, 2B5I, 1ILM, 3NFP, 2ERJ, 1Z92, 1ILN
UniProt P01589, Q5W005
Vega OTTHUMG00000017616
MIM 147730
Ensembl ENSG00000134460
HGNC 6008
HPRD 00986

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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