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IL13 interleukin 13 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002188 Homo sapiens interleukin 13 (IL13), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

Related Services

Gene Symbol IL13
Entrez Gene ID 3596
Full Name interleukin 13
Synonyms ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31

Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008].
Disorder

MIM: 147683

{Asthma, susceptibility to}, 600807 (3); {Allergic rhinitis,

mRNA Protein Product Sequence Price Select
NM_002188, 26787977 NP_002179, 26787978 interleukin-13 precursor ORF Sequence $99.00
KEGG
hsa05162Measles
hsa04664Fc epsilon RI signaling pathway
hsa05310Asthma
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway Interaction Database
reg_gr_pathwayGlucocorticoid receptor regulatory network
il12_stat4pathwayIL12 signaling mediated by STAT4
WikiPathways
WP706SIDS Susceptibility Pathways
WP530Cytokines and Inflammatory Response
Homo sapiens (human)IL13NP_002179.2
Pan troglodytes (chimpanzee)IL13NP_001008992.1
Macaca mulatta (Rhesus monkey)IL13NP_001028101.1
Canis lupus familiaris (dog)IL13NP_001003384.1
Bos taurus (cattle)IL13NP_776514.1
Mus musculus (house mouse)Il13NP_032381.1
Rattus norvegicus (Norway rat)Il13NP_446280.1
GeneCards IL13
PDB 3ITR, 3L5X, 4I77, 3LB6, 3L5W, 1J9U, 1IJZ, 1GA3, 1IK0, 3ITS, 3L5Y, 3G6D, 3BPO
UniProt P35225
MIM 147683
Ensembl ENSG00000169194
HGNC 5973
HPRD 00981

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
interleukin-13
Names
interleukin-13

Interactant



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