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INPPL1 inositol polyphosphate phosphatase-like 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001567 Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol INPPL1
Entrez Gene ID 3636
Full Name inositol polyphosphate phosphatase-like 1
Synonyms SHIP2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13

Summary The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009].
Disorder

MIM: 600829

mRNA Protein Product Sequence Price Select
NM_001567, 222136582 NP_001558, 222136583 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 ORF Sequence $1500.00
KEGG
hsa04910Insulin signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04662B cell receptor signaling pathway
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
WikiPathways
WP364IL-6 Signaling Pathway
WP437EGFR1 Signaling Pathway
WP481Insulin Signaling
Pathway Interaction Database
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
epha2_fwdpathwayEPHA2 forward signaling
pi3kcipathwayClass I PI3K signaling events
BIOCYC
HUMAN_PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
META_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
HUMAN_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
META_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HUMAN_PWY-63683-phosphoinositide degradation
META_PWY-63683-phosphoinositide degradation
HUMAN_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HUMAN_PWY-6371superpathway of inositol phosphate compounds
HUMAN_PWY-6363D-myo-inositol (1,4,5)-trisphosphate degradation
META_PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
Reactome
REACT_121175PI Metabolism
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_27283Interleukin-2 signaling
REACT_22232Signaling by Interleukins
REACT_22258Metabolism of lipids and lipoproteins
REACT_6900Immune System
REACT_111217Metabolism
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_120870Phospholipid metabolism
REACT_75790Cytokine Signaling in Immune system
REACT_23891Interleukin receptor SHC signaling
Homo sapiens (human)INPPL1NP_001558.3
Pan troglodytes (chimpanzee)INPPL1XP_508622.2
Macaca mulatta (Rhesus monkey)INPPL1XP_001114794.1
Canis lupus familiaris (dog)INPPL1XP_542327.2
Bos taurus (cattle)INPPL1NP_001178105.1
Mus musculus (house mouse)Inppl1NP_034697.2
Rattus norvegicus (Norway rat)Inppl1NP_075233.1
Danio rerio (zebrafish)inppl1aNP_001034893.1
GeneCards INPPL1
PDB 3NR8, 4A9C, 2KSO, 2K4P
UniProt O15357
MIM 600829
Ensembl ENSG00000165458
HGNC 6080
HPRD 02900

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
SHIP-2
INPPL-1
51C protein
protein 51C
SH2 domain-containing inositol 5'-phosphatase 2
SH2 domain-containing inositol-5'-phosphatase 2
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
NP_001558.3

Interactant



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