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Sequence in raw or FASTA format:

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INPPL1 inositol polyphosphate phosphatase-like 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001567 Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005273978 PREDICTED: Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005273979 PREDICTED: Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006718534 PREDICTED: Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006718535 PREDICTED: Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006718536 PREDICTED: Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006718537 PREDICTED: Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol INPPL1
Entrez Gene ID 3636
Full Name inositol polyphosphate phosphatase-like 1
Synonyms OPSMD, SHIP2
General protein information
Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
SHIP-2
INPPL-1
51C protein
protein 51C
SH2 domain-containing inositol 5'-phosphatase 2
SH2 domain-containing inositol-5'-phosphatase 2
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
NP_001558.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13

Summary The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009].
Disorder

MIM: 600829

mRNA Protein Product Sequence Price Select
NM_001567, 222136582 NP_001558, 222136583 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 ORF Sequence $1500.00
XM_005273978, 578821372 XP_005274035, 530396742 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 ORF Sequence $1500.00
XM_005273979, 578821373 XP_005274036, 530396744 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2 ORF Sequence $1500.00
XM_006718534, 578821374 XP_006718597, 578821375 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3 ORF Sequence $1500.00
XM_006718535, 578821376 XP_006718598, 578821377 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4 ORF Sequence $1500.00
XM_006718536, 578821378 XP_006718599, 578821379 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5 ORF Sequence $1500.00
XM_006718537, 578821380 XP_006718600, 578821381 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X6 ORF Sequence $1500.00
KEGG
hsa00562Inositol phosphate metabolism
hsa04662B cell receptor signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04910Insulin signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
WikiPathways
WP437EGFR1 Signaling Pathway
WP481Insulin Signaling
WP364IL-6 Signaling Pathway
Pathway Interaction Database
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
epha2_fwdpathwayEPHA2 forward signaling
pi3kcipathwayClass I PI3K signaling events
BIOCYC
META_PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
HUMAN_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
HUMAN_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
HUMAN_PWY-6363D-myo-inositol (1,4,5)-trisphosphate degradation
HUMAN_PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
HUMAN_PWY-63683-phosphoinositide degradation
HUMAN_PWY-6371superpathway of inositol phosphate compounds
Reactome
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_22258Metabolism of lipids and lipoproteins
REACT_27283Interleukin-2 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_111217Metabolism
REACT_121175PI Metabolism
REACT_120870Phospholipid metabolism
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_150154Inositol phosphate metabolism
REACT_150312Synthesis of IP3 and IP4 in the cytosol
Homo sapiens (human)INPPL1NP_001558.3
Pan troglodytes (chimpanzee)INPPL1XP_508622.2
Macaca mulatta (Rhesus monkey)INPPL1XP_001114794.1
Canis lupus familiaris (dog)INPPL1XP_542327.2
Bos taurus (cattle)INPPL1NP_001178105.1
Mus musculus (house mouse)Inppl1NP_001116211.1
Rattus norvegicus (Norway rat)Inppl1NP_075233.1
Danio rerio (zebrafish)inppl1aNP_001034893.1
Process
IDNameEvidence
GO:0001958endochondral ossificationIMP
GO:0002376immune system processIEA
GO:0006006glucose metabolic processIEA
GO:0006644phospholipid metabolic processTAS
GO:0006661phosphatidylinositol biosynthetic processTAS
GO:0006897endocytosisIMP
GO:0007015actin filament organizationIMP
GO:0007155cell adhesionTAS
GO:0008285negative regulation of cell proliferationIEA
GO:0009791post-embryonic developmentIEA
GO:0010629negative regulation of gene expressionIEA
GO:0032868response to insulinIEA
GO:0043647inositol phosphate metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0046856phosphatidylinositol dephosphorylationIEA
GO:0097178ruffle assemblyIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIDA
GO:0005829cytosolTAS
GO:0005856cytoskeletonIEA
GO:0005886plasma membraneIEA
GO:0030027lamellipodiumIEA
GO:0030175filopodiumIEA
Function
IDNameEvidence
GO:0003779actin bindingIEA
GO:0005515protein bindingIPI
GO:0016787hydrolase activityIEA
GO:0017124SH3 domain bindingIEA
GO:0042169SH2 domain bindingIPI
GeneCards INPPL1
UniProt O15357
Vega OTTHUMG00000167879
MIM 600829
Ensembl ENSG00000165458
HGNC 6080
HPRD 02900

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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