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ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23700 NM_033453 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu23830 NM_181493 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu23901 NM_001267623 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu52713 XM_006723564 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu52714 XM_006723565 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu23700C NM_033453 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu23830C NM_181493 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu23901C NM_001267623 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 3, mRNA. Customized vector On-demand 7-9 $209.00
OHu52713C XM_006723564 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu52714C XM_006723565 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol ITPA
Entrez Gene ID 3704
Full Name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Synonyms C20orf37, HLC14-06-P, dJ794I6.3
General protein information
Preferred Names
inosine triphosphate pyrophosphatase
Names
inosine triphosphate pyrophosphatase
ITPase
NTPase
inosine triphosphatase-A
putative oncogene protein HLC14-06-P
nucleoside-triphosphate diphosphatase
non-standard purine NTP pyrophosphatase
non-canonical purine NTP pyrophosphatase
inosine triphosphate pyrophosphohydrolase
NP_001254552.1
NP_258412.1
NP_852470.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20p

Summary This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
Disorder

MIM: 147520

[Inosine triphosphatase deficiency] (3)

mRNA Protein Product Sequence Price Select
NM_001267623, 390517019 NP_001254552, 390517020 inosine triphosphate pyrophosphatase isoform c ORF Sequence $150.00
NM_033453, 390517017 NP_258412, 15626999 inosine triphosphate pyrophosphatase isoform a ORF Sequence $159.00
NM_181493, 390517018 NP_852470, 31657144 inosine triphosphate pyrophosphatase isoform b ORF Sequence $250.00
XM_006723564, 578835408 XP_006723627, 578835409 inosine triphosphate pyrophosphatase isoform X1 ORF Sequence $250.00
XM_006723565, 578835410 XP_006723628, 578835411 inosine triphosphate pyrophosphatase isoform X2 ORF Sequence $250.00
KEGG
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
Reactome
REACT_1698Metabolism of nucleotides
REACT_111217Metabolism
Homo sapiens (human)ITPANP_258412.1
Pan troglodytes (chimpanzee)ITPAXP_003953718.1
Macaca mulatta (Rhesus monkey)ITPAXP_001115179.1
Canis lupus familiaris (dog)ITPAXP_851574.3
Bos taurus (cattle)ITPANP_001069750.1
Mus musculus (house mouse)ItpaNP_080198.2
Rattus norvegicus (Norway rat)ItpaNP_001101244.1
Gallus gallus (chicken)ITPANP_001258859.1
Danio rerio (zebrafish)itpaXP_005160503.1
Danio rerio (zebrafish)LOC101882233XP_005160507.1
Drosophila melanogaster (fruit fly)CG8891NP_608890.1
Caenorhabditis eleganshap-1NP_498121.1
Arabidopsis thaliana (thale cress)AT4G13720NP_567410.1
Xenopus (Silurana) tropicalis (western clawed frog)itpaXP_002934214.1
Process
IDNameEvidence
GO:0006193ITP catabolic processIEA
GO:0009204deoxyribonucleoside triphosphate catabolic processIEA
GO:0044281small molecule metabolic processTAS
GO:0051276chromosome organizationIEA
GO:0055086nucleobase-containing small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0035870dITP diphosphatase activityEXP
GO:0036220ITP diphosphatase activityEXP
GO:0036222XTP diphosphatase activityEXP
GO:0046872metal ion bindingIEA
GeneCards ITPA
UniProt Q9BY32
Vega OTTHUMG00000031738
MIM 147520
Ensembl ENSG00000125877
HGNC 6176
HPRD 08856

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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