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ARF1 ADP-ribosylation factor 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001024226 Homo sapiens ADP-ribosylation factor 1 (ARF1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001024227 Homo sapiens ADP-ribosylation factor 1 (ARF1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001024228 Homo sapiens ADP-ribosylation factor 1 (ARF1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001658 Homo sapiens ADP-ribosylation factor 1 (ARF1), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol ARF1
Entrez Gene ID 375
Full Name ADP-ribosylation factor 1
Synonyms
General protein information
Preferred Names
ADP-ribosylation factor 1
Names
ADP-ribosylation factor 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q42

Summary ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 103180

mRNA Protein Product Sequence Price Select
NM_001024226, 66879659 NP_001019397, 66879660 ADP-ribosylation factor 1 ORF Sequence $159.00
NM_001024227, 66879661 NP_001019398, 66879662 ADP-ribosylation factor 1 ORF Sequence $159.00
NM_001024228, 66879663 NP_001019399, 66879664 ADP-ribosylation factor 1 ORF Sequence $159.00
NM_001658, 66879658 NP_001649, 4502201 ADP-ribosylation factor 1 ORF Sequence $159.00
KEGG
hsa05110Vibrio cholerae infection
hsa05134Legionellosis
WikiPathways
WP481Insulin Signaling
WP179Cell cycle
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
arf_3pathwayArf1 pathway
pi3kcipathwayClass I PI3K signaling events
arf6downstreampathwayArf6 downstream pathway
Reactome
REACT_19187Clathrin derived vesicle budding
REACT_19287Lysosome Vesicle Biogenesis
REACT_19400Golgi Associated Vesicle Biogenesis
REACT_6185HIV Infection
REACT_6835The role of Nef in HIV-1 replication and disease pathogenesis
REACT_11149Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
REACT_6288Host Interactions of HIV factors
REACT_11166Nef Mediated CD4 Down-regulation
REACT_11123Membrane Trafficking
REACT_11235trans-Golgi Network Vesicle Budding
REACT_11208Golgi to ER Retrograde Transport
REACT_11096COPI Mediated Transport
REACT_6900Immune System
REACT_22258Metabolism of lipids and lipoproteins
REACT_75774Adaptive Immune System
REACT_111217Metabolism
REACT_116125Disease
REACT_121175PI Metabolism
REACT_120836Synthesis of PIPs at the Golgi membrane
REACT_120870Phospholipid metabolism
REACT_121399MHC class II antigen presentation
Homo sapiens (human)ARF1NP_001019399.1
Pan troglodytes (chimpanzee)ARF1XP_001145129.1
Pan troglodytes (chimpanzee)LOC457177XP_513698.2
Macaca mulatta (Rhesus monkey)ARF1XP_002801945.1
Canis lupus familiaris (dog)LOC607365NP_001238856.1
Bos taurus (cattle)ARF1NP_788826.1
Mus musculus (house mouse)Arf1NP_031502.1
Rattus norvegicus (Norway rat)Arf1NP_071963.1
Gallus gallus (chicken)ARF1NP_001006352.1
Danio rerio (zebrafish)arf1NP_958860.1
Drosophila melanogaster (fruit fly)Arf79FNP_730760.1
Caenorhabditis elegansarf-1.2NP_498235.1
Xenopus (Silurana) tropicalis (western clawed frog)arf5NP_989018.1
Process
IDNameEvidence
GO:0002090regulation of receptor internalizationISS
GO:0006184GTP catabolic processTAS
GO:0006644phospholipid metabolic processTAS
GO:0006661phosphatidylinositol biosynthetic processTAS
GO:0006878cellular copper ion homeostasisIMP
GO:0006890retrograde vesicle-mediated transport, Golgi to ERTAS
GO:0006892post-Golgi vesicle-mediated transportTAS
GO:0007264small GTPase mediated signal transductionIEA
GO:0015031protein transportIEA
GO:0016032viral processTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0034315regulation of Arp2/3 complex-mediated actin nucleationISS
GO:0044281small molecule metabolic processTAS
GO:0048205COPI coating of Golgi vesicleTAS
GO:0050690regulation of defense response to virus by virusTAS
GO:0060292long term synaptic depressionISS
GO:0061024membrane organizationTAS
GO:0097061dendritic spine organizationISS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005829cytosolTAS
GO:0005886plasma membraneTAS
GO:0014069postsynaptic densityIEA
GO:0030017sarcomereIEA
GO:0030054cell junctionIEA
GO:0043005neuron projectionIEA
GO:0045211postsynaptic membraneIEA
GO:0048471perinuclear region of cytoplasmIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003924GTPase activityTAS
GO:0005057receptor signaling protein activityTAS
GO:0005515protein bindingIPI
GO:0005525GTP bindingIEA
GO:0044822poly(A) RNA bindingIDA
GeneCards ARF1
PDB 1RE0, 1HUR, 1U81, 4HMY, 3O47
UniProt P84077
Vega OTTHUMG00000037595
MIM 103180
Ensembl ENSG00000143761
HGNC 652
HPRD 00054

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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