ARF1 ADP-ribosylation factor 1 [Homo sapiens (human)]
| Gene Symbol | ARF1 |
| Entrez Gene ID | 375 |
| Full Name | ADP-ribosylation factor 1 |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q42 |
| Summary | ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 103180 |
| mRNA | NM_001024226, 66879659 |
| Protein | NP_001019397, 66879660 |
| Product | ADP-ribosylation factor 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001024227, 66879661 |
| Protein | NP_001019398, 66879662 |
| Product | ADP-ribosylation factor 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001658, 66879658 |
| Protein | NP_001649, 4502201 |
| Product | ADP-ribosylation factor 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001024228, 66879663 |
| Protein | NP_001019399, 66879664 |
| Product | ADP-ribosylation factor 1 |
| RefSeq Status | REVIEWED |
| hsa05110 | Vibrio cholerae infection |
WikiPathways
| WP481 | Insulin Signaling |
Pathway Interaction Database
| arf_3pathway | Arf1 pathway |
| pi3kcipathway | Class I PI3K signaling events |
| arf6downstreampathway | Arf6 downstream pathway |
Reactome
| REACT_11208 | Golgi to ER Retrograde Transport |
| REACT_11235 | trans-Golgi Network Vesicle Budding |
| REACT_11123 | Membrane Trafficking |
| REACT_19400 | Golgi Associated Vesicle Biogenesis |
| REACT_11166 | Nef Mediated CD4 Down-regulation |
| REACT_6288 | Host Interactions of HIV factors |
| REACT_11149 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REACT_19187 | Clathrin derived vesicle budding |
| REACT_11096 | COPI Mediated Transport |
| REACT_19287 | Lysosome Vesicle Biogenesis |
| REACT_6835 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REACT_6185 | HIV Infection |
| Homo sapiens (human) | ARF1 | NP_001019397.1 |
| Pan troglodytes (chimpanzee) | LOC739225 | XP_001145210.1 |
| Pan troglodytes (chimpanzee) | LOC457177 | XP_513698.2 |
| Canis lupus familiaris (dog) | ARF1 | XP_531820.1 |
| Bos taurus (cattle) | ARF1 | NP_788826.1 |
| Mus musculus (house mouse) | Arf1 | NP_031502.1 |
| Rattus norvegicus (Norway rat) | Arf1 | NP_071963.1 |
| Gallus gallus (chicken) | ARF1 | NP_001006352.1 |
| Danio rerio (zebrafish) | arf1 | NP_958860.1 |
| Drosophila melanogaster (fruit fly) | Arf79F | NP_730757.1 |
| Caenorhabditis elegans | arf-1.2 | NP_498235.1 |
| Arabidopsis thaliana (thale cress) | ATARFA1E | NP_191788.1 |
| Arabidopsis thaliana (thale cress) | ATARFA1F | NP_172533.2 |
| Arabidopsis thaliana (thale cress) | ARF1A1C | NP_182239.1 |
| Arabidopsis thaliana (thale cress) | ATARF1 | NP_564195.1 |
| Arabidopsis thaliana (thale cress) | ARFA1D | NP_974120.1 |
| ID | Name | Evidence |
| GO:0006184 | GTP catabolic process | TAS |
| GO:0006878 | cellular copper ion homeostasis | IMP |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | EXP |
| GO:0006892 | post-Golgi vesicle-mediated transport | EXP |
| GO:0007264 | small GTPase mediated signal transduction | IEA |
| GO:0015031 | protein transport | IEA |
| GO:0016032 | viral reproduction | TAS |
| GO:0016044 | cellular membrane organization | EXP |
| GO:0016192 | vesicle-mediated transport | IEA |
| GO:0048205 | COPI coating of Golgi vesicle | EXP |
| GO:0050690 | regulation of defense response to virus by virus | TAS |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | EXP |
| GO:0000139 | Golgi membrane | TAS |
| GO:0005622 | intracellular | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005886 | plasma membrane | TAS |
| GO:0048471 | perinuclear region of cytoplasm | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003924 | GTPase activity | TAS |
| GO:0005057 | receptor signaling protein activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | IEA |
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