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NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [Gallus gallus (chicken)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_205378 Gallus gallus neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol NTRK1
Entrez Gene ID 396337
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms CTRKA, trkA
General protein information
Preferred Names
high affinity nerve growth factor receptor
Names
high affinity nerve growth factor receptor
trk-A
tropomyosin receptor kinase
neurotrophic tyrosine kinase receptor type 1
NP_990709.1
Gene Type protein-coding
Organism Gallus gallus (chicken)
Genome

25

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_205378, 45382412 NP_990709, 45382413 high affinity nerve growth factor receptor precursor ORF Sequence $750.00
KEGG
gga04010MAPK signaling pathway
gga04210Apoptosis
gga04144Endocytosis
WikiPathways
WP769MAPK signaling pathway
Homo sapiens (human)NTRK1NP_002520.2
Pan troglodytes (chimpanzee)NTRK1XP_003308563.1
Macaca mulatta (Rhesus monkey)NTRK1XP_001114243.2
Canis lupus familiaris (dog)NTRK1XP_851619.3
Bos taurus (cattle)NTRK1XP_002686012.2
Mus musculus (house mouse)Ntrk1NP_001028296.1
Rattus norvegicus (Norway rat)Ntrk1NP_067600.1
Gallus gallus (chicken)NTRK1NP_990709.1
Danio rerio (zebrafish)ntrk1XP_697246.5
Xenopus (Silurana) tropicalis (western clawed frog)ntrk1XP_002939035.1
Process
IDNameEvidence
GO:0006468protein phosphorylationISS
GO:0008285negative regulation of cell proliferationISS
GO:0010976positive regulation of neuron projection developmentISS
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0018108peptidyl-tyrosine phosphorylationISS
GO:0032320positive regulation of Ras GTPase activityISS
GO:0038180nerve growth factor signaling pathwayISS
GO:0043524negative regulation of neuron apoptotic processISS
GO:0046579positive regulation of Ras protein signal transductionISS
GO:0046777protein autophosphorylationISS
GO:0048011neurotrophin TRK receptor signaling pathwayISS
GO:0048485sympathetic nervous system developmentISS
GO:0051092positive regulation of NF-kappaB transcription factor activityISS
GO:0060385axonogenesis involved in innervationISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
Component
IDNameEvidence
GO:0005887integral component of plasma membraneISS
GO:0031901early endosome membraneIEA
GO:0031902late endosome membraneIEA
Function
IDNameEvidence
GO:0004714transmembrane receptor protein tyrosine kinase activityISS
GO:0005524ATP bindingIEA
GO:0010465nerve growth factor receptor activityISS
GO:0042803protein homodimerization activityISS
GO:0048406nerve growth factor bindingISS
GeneCards NTRK1
UniProt Q90699
CGNC 49757
Ensembl ENSGALG00000019019

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NTRK1 gene?

The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons). The NTRK1 protein is found on the surface of cells, particularly sensory neurons. It acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. This process is called phosphorylation. The NTRK1 protein is turned on (activated) when another protein called nerve growth factor beta (NGFβ) attaches (binds) to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). Then, the activated NTRK1 protein phosphorylates other proteins; this process is needed to transmit signals for cell growth and survival.

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