PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Gallus gallus (chicken)]
| Gene Symbol | PTGS2 |
| Entrez Gene ID | 396451 |
| Full Name | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| Synonyms | CEF147, PGHS2, PHSII |
| Gene Type | protein-coding |
| Organism | Gallus gallus (chicken) |
| Genome |
8 |
| Summary | |
| Disorder | MIM: |
| mRNA | NM_001167719, 268370253 |
| Protein | NP_001161191, 268370254 |
| Product | prostaglandin G/H synthase 2 isoform 1 |
| RefSeq Status | VALIDATED |
| mRNA | NM_001167718, 268370249 |
| Protein | NP_001161190, 268370250 |
| Product | prostaglandin G/H synthase 2 isoform 2 |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | PTGS2 | NP_000954.1 |
| Pan troglodytes (chimpanzee) | PTGS2 | XP_524999.2 |
| Canis lupus familiaris (dog) | PTGS2 | NP_001003354.1 |
| Bos taurus (cattle) | PTGS2 | NP_776870.1 |
| Mus musculus (house mouse) | Ptgs2 | NP_035328.2 |
| Rattus norvegicus (Norway rat) | Ptgs2 | NP_058928.2 |
| Gallus gallus (chicken) | PTGS2 | XP_422297.1 |
| Danio rerio (zebrafish) | ptgs2b | NP_001020675.1 |
| ID | Name | Evidence |
| GO:0006633 | fatty acid biosynthetic process | IEA |
| GO:0006979 | response to oxidative stress | IEA |
| GO:0008217 | regulation of blood pressure | ISS |
| GO:0019371 | cyclooxygenase pathway | IEA |
| GO:0031622 | positive regulation of fever generation | IEA |
| GO:0042127 | regulation of cell proliferation | IEA |
| GO:0042640 | anagen | IEA |
| GO:0055114 | oxidation-reduction process | IEA |
| GO:0090336 | positive regulation of brown fat cell differentiation | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | ISS |
| GO:0005737 | cytoplasm | ISS |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005789 | endoplasmic reticulum membrane | IEA |
| GO:0005792 | microsome | IEA |
| GO:0016020 | membrane | IEA |
| GO:0043005 | neuron projection | IEA |
Function
| ID | Name | Evidence |
| GO:0004601 | peroxidase activity | IEA |
| GO:0004666 | prostaglandin-endoperoxide synthase activity | IEA |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | IEA |
| GO:0019899 | enzyme binding | IEA |
| GO:0020037 | heme binding | IEA |
| GO:0046872 | metal ion binding | IEA |
| GeneCards | PTGS2 |
| UniProt | P27607 |
| CGNC | 3769 |
| Ensembl | ENSGALG00000005069 |
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