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Sequence in raw or FASTA format:

Database:

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TNF tumor necrosis factor [Sus scrofa (pig)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OSe30520 NM_214022 Sus scrofa tumor necrosis factor (TNF), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OSe30520C NM_214022 Sus scrofa tumor necrosis factor (TNF), mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol TNF
Entrez Gene ID 397086
Full Name tumor necrosis factor
Synonyms TNFa
General protein information
Preferred Names
tumor necrosis factor
Names
tumor necrosis factor
TNF-a
TNF-alpha
cachectin
tumor-necrosis factor
tumor necrosis factor alpha
tumor necrosis factor (TNF superfamily, member 2)
tumor necrosis factor ligand superfamily member 2
Gene Type protein-coding
Organism Sus scrofa (pig)
Genome

7

7p11-q11|7

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_214022, 47522865 NP_999187, 47522866 tumor necrosis factor ORF Sequence $250.00
KEGG
ssc04010MAPK signaling pathway
ssc04150mTOR signaling pathway
ssc04210Apoptosis
ssc04640Hematopoietic cell lineage
ssc04660T cell receptor signaling pathway
ssc04664Fc epsilon RI signaling pathway
ssc04060Cytokine-cytokine receptor interaction
ssc04350TGF-beta signaling pathway
ssc04650Natural killer cell mediated cytotoxicity
ssc04612Antigen processing and presentation
ssc04920Adipocytokine signaling pathway
ssc04620Toll-like receptor signaling pathway
ssc04930Type II diabetes mellitus
ssc04940Type I diabetes mellitus
ssc05330Allograft rejection
ssc05322Systemic lupus erythematosus
ssc05332Graft-versus-host disease
ssc05010Alzheimer's disease
ssc05310Asthma
ssc05014Amyotrophic lateral sclerosis (ALS)
ssc04622RIG-I-like receptor signaling pathway
ssc05414Dilated cardiomyopathy
ssc04621NOD-like receptor signaling pathway
ssc05410Hypertrophic cardiomyopathy (HCM)
ssc05142Chagas disease (American trypanosomiasis)
ssc05140Leishmaniasis
ssc05145Toxoplasmosis
ssc05144Malaria
ssc05146Amoebiasis
ssc05160Hepatitis C
ssc05143African trypanosomiasis
ssc05323Rheumatoid arthritis
ssc05166HTLV-I infection
ssc05152Tuberculosis
ssc04380Osteoclast differentiation
ssc05164Influenza A
ssc05168Herpes simplex infection
ssc05133Pertussis
ssc05134Legionellosis
ssc05161Hepatitis B
ssc05205Proteoglycans in cancer
ssc04064NF-kappa B signaling pathway
ssc05321Inflammatory bowel disease (IBD)
ssc04668TNF signaling pathway
ssc04932Non-alcoholic fatty liver disease (NAFLD)
Reactome
5441626Developmental Biology
5442206Transcriptional regulation of white adipocyte differentiation
5441420Extrinsic Pathway for Apoptosis
5441421Apoptosis
5441557TNF signaling
5441419Death Receptor Signalling
Process
IDNameEvidence
GO:0000060protein import into nucleus, translocationIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0000185activation of MAPKKK activityIEA
GO:0000187activation of MAPK activityIEA
GO:0002439chronic inflammatory response to antigenic stimulusIEA
GO:0002740negative regulation of cytokine secretion involved in immune responseIEA
GO:0002876positive regulation of chronic inflammatory response to antigenic stimulusIEA
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulinIEA
GO:0006006glucose metabolic processIEA
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIEA
GO:0006927transformed cell apoptotic processIEA
GO:0006959humoral immune responseIEA
GO:0007254JNK cascadeIEA
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIEA
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIEA
GO:0008652cellular amino acid biosynthetic processIEA
GO:0009615response to virusIEA
GO:0009887organ morphogenesisIEA
GO:0010693negative regulation of alkaline phosphatase activityIEA
GO:0030198extracellular matrix organizationIEA
GO:0030316osteoclast differentiationIEA
GO:0030730sequestering of triglycerideIEA
GO:0031622positive regulation of fever generationIEA
GO:0031663lipopolysaccharide-mediated signaling pathwayIEA
GO:0032715negative regulation of interleukin-6 productionIEA
GO:0032729positive regulation of interferon-gamma productionIEA
GO:0032755positive regulation of interleukin-6 productionIEA
GO:0032800receptor biosynthetic processIEA
GO:0033138positive regulation of peptidyl-serine phosphorylationIEA
GO:0033209tumor necrosis factor-mediated signaling pathwayIEA
GO:0034116positive regulation of heterotypic cell-cell adhesionIEA
GO:0042346positive regulation of NF-kappaB import into nucleusIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIEA
GO:0043242negative regulation of protein complex disassemblyIEA
GO:0043243positive regulation of protein complex disassemblyIEA
GO:0043491protein kinase B signalingIEA
GO:0043507positive regulation of JUN kinase activityIEA
GO:0044130negative regulation of growth of symbiont in hostIEA
GO:0045071negative regulation of viral genome replicationIEA
GO:0045080positive regulation of chemokine biosynthetic processIEA
GO:0045416positive regulation of interleukin-8 biosynthetic processIEA
GO:0045429positive regulation of nitric oxide biosynthetic processIEA
GO:0045668negative regulation of osteoblast differentiationIEA
GO:0045672positive regulation of osteoclast differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0045994positive regulation of translational initiation by ironIEA
GO:0046325negative regulation of glucose importIEA
GO:0046330positive regulation of JNK cascadeIEA
GO:0048566embryonic digestive tract developmentIEA
GO:0048661positive regulation of smooth muscle cell proliferationIEA
GO:0050715positive regulation of cytokine secretionIEA
GO:0050796regulation of insulin secretionIEA
GO:0050830defense response to Gram-positive bacteriumIEA
GO:0050901leukocyte tethering or rollingIEA
GO:0050995negative regulation of lipid catabolic processIEA
GO:0051023regulation of immunoglobulin secretionIEA
GO:0051044positive regulation of membrane protein ectodomain proteolysisIEA
GO:0051092positive regulation of NF-kappaB transcription factor activityIEA
GO:0051384response to glucocorticoidIEA
GO:0051533positive regulation of NFAT protein import into nucleusIEA
GO:0051798positive regulation of hair follicle developmentIEA
GO:0051897positive regulation of protein kinase B signalingIEA
GO:0060557positive regulation of vitamin D biosynthetic processIEA
GO:0060559positive regulation of calcidiol 1-monooxygenase activityIEA
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIEA
GO:0060693regulation of branching involved in salivary gland morphogenesisIEA
GO:0061048negative regulation of branching involved in lung morphogenesisIEA
GO:0071230cellular response to amino acid stimulusIEA
GO:0071316cellular response to nicotineIEA
GO:0071803positive regulation of podosome assemblyIEA
GO:0097527necroptotic signaling pathwayISS
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA
GO:2000010positive regulation of protein localization to cell surfaceIEA
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 productionIEA
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA
Component
IDNameEvidence
GO:0001891phagocytic cupIEA
GO:0005615extracellular spaceIEA
GO:0005887integral component of plasma membraneIEA
GO:0009897external side of plasma membraneIEA
GO:0045121membrane raftIEA
GO:0055037recycling endosomeIEA
Function
IDNameEvidence
GO:0002020protease bindingIEA
GO:0005125cytokine activityIEA
GO:0005164tumor necrosis factor receptor bindingIEA
GO:0042802identical protein bindingIEA
GO:0044212transcription regulatory region DNA bindingIEA
GeneCards TNF
UniProt P23563, B3GDZ6
Vega OTTSUSG00000001322
Ensembl ENSSSCG00000001404

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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