Sequence in raw or FASTA format:
COL4A4 collagen, type IV, alpha 4 [Bos taurus (cattle)]
|Entrez Gene ID||407107|
|Full Name||collagen, type IV, alpha 4|
|General protein information||
|Organism||Bos taurus (cattle)|
|bta05222||Small cell lung cancer|
|bta05200||Pathways in cancer|
|bta04974||Protein digestion and absorption|
|bta04151||PI3K-Akt signaling pathway|
|GO:0005587||collagen type IV trimer||IDA|
|GO:0005201||extracellular matrix structural constituent||IEA|
What is the normal function of the COL4A4 gene?
The COL4A4 gene provides instructions for making one component of type IV collagen, which is a flexible protein. Specifically, this gene makes the alpha4(IV) chain of type IV collagen. This chain combines with two other types of alpha (IV) chains (the alpha3 and alpha5 chains) to make a complete type IV collagen molecule. Type IV collagen molecules attach to each other to form complex protein networks. These networks make up a large portion of basement membranes, which are thin sheet-like structures that separate and support cells in many tissues. Type IV collagen alpha3-4-5 networks play an especially important role in the basement membranes of the kidney, inner ear, and eye.
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