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COL2A1 collagen, type II, alpha 1 [Bos taurus (cattle)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001001135 Bos taurus collagen, type II, alpha 1 (COL2A1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001113224 Bos taurus collagen, type II, alpha 1 (COL2A1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol COL2A1
Entrez Gene ID 407142
Full Name collagen, type II, alpha 1
Synonyms CB11
General protein information
Preferred Names
collagen alpha-1(II) chain
Names
collagen alpha-1(II) chain
pro-alpha 1(II)
cyanogen bromide
alpha-1 type II collagen
Gene Type protein-coding
Organism Bos taurus (cattle)
Genome

5

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001001135, 164414424 NP_001001135, 164414425 collagen alpha-1(II) chain isoform 1 precursor ORF Sequence $1500.00
NM_001113224, 164414426 NP_001106695, 164414427 collagen alpha-1(II) chain isoform 2 precursor ORF Sequence $1500.00
KEGG
bta04510Focal adhesion
bta04512ECM-receptor interaction
bta05146Amoebiasis
bta04974Protein digestion and absorption
bta04151PI3K-Akt signaling pathway
bta04611Platelet activation
WikiPathways
WP1065Endochondral Ossification
Reactome
5493857Extracellular matrix organization
5494646Assembly of collagen fibrils and other multimeric structures
5494647Collagen formation
5494674Collagen biosynthesis and modifying enzymes
Homo sapiens (human)COL2A1NP_001835.3
Pan troglodytes (chimpanzee)COL2A1XP_509026.2
Macaca mulatta (Rhesus monkey)COL2A1XP_001100739.1
Canis lupus familiaris (dog)COL2A1NP_001006952.1
Bos taurus (cattle)COL2A1NP_001001135.2
Mus musculus (house mouse)Col2a1NP_112440.2
Rattus norvegicus (Norway rat)Col2a1NP_037061.1
Gallus gallus (chicken)COL2A1NP_989757.1
Danio rerio (zebrafish)col2a1aNP_571367.1
Xenopus (Silurana) tropicalis (western clawed frog)col2a1NP_989220.1
Process
IDNameEvidence
GO:0001502cartilage condensationIEA
GO:0001894tissue homeostasisIEA
GO:0001958endochondral ossificationIEA
GO:0002062chondrocyte differentiationIEA
GO:0003007heart morphogenesisIEA
GO:0006029proteoglycan metabolic processIEA
GO:0007417central nervous system developmentIEA
GO:0007601visual perceptionIEA
GO:0007605sensory perception of soundIEA
GO:0010468regulation of gene expressionIEA
GO:0030199collagen fibril organizationIEA
GO:0030903notochord developmentIEA
GO:0042472inner ear morphogenesisIEA
GO:0060021palate developmentIEA
GO:0060174limb bud formationIEA
GO:0060272embryonic skeletal joint morphogenesisIEA
GO:0060351cartilage development involved in endochondral bone morphogenesisIEA
GO:0071599otic vesicle developmentIEA
GO:0071773cellular response to BMP stimulusIEA
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005585collagen type II trimerIEA
GO:0005604basement membraneIEA
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0005201extracellular matrix structural constituentIEA
GO:0042802identical protein bindingIEA
GO:0046872metal ion bindingIEA
GO:0048407platelet-derived growth factor bindingIEA
GeneCards COL2A1
UniProt P02459, F1MSR8
Ensembl ENSBTAG00000013155

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the COL2A1 gene?

The COL2A1 gene provides instructions for making one component of type II collagen, called the pro-alpha1(II) chain. Type II collagen adds structure and strength to the connective tissues that support the body's muscles, joints, organs, and skin. Type II collagen is found primarily in cartilage, a tough but flexible tissue that makes up much of the skeleton during early development. Most cartilage is later converted to bone, except for the cartilage that continues to cover and protect the ends of bones and is present in the nose and external ears. Type II collagen is also part of the clear gel that fills the eyeball (the vitreous), the inner ear, and the center portion of the discs between the vertebrae in the spine (nucleus pulposus).

To construct type II collagen, three pro-alpha1(II) chains twist together to form a triple-stranded, ropelike procollagen molecule. Procollagen molecules are then processed by enzymes in the cell. Once processed, the molecules leave the cell and arrange themselves into long, thin fibrils that link to one another (cross-link) in the spaces around cells. The cross-linkages result in the formation of very strong, mature type II collagen fibers.

Interactant

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