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M6PR mannose-6-phosphate receptor (cation dependent) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19246 NM_002355 Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19557 NM_001207024 Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu19246 XM_005253376 PREDICTED: Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu19246C NM_002355 Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu19557C NM_001207024 Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu19246C XM_005253376 PREDICTED: Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol M6PR
Entrez Gene ID 4074
Full Name mannose-6-phosphate receptor (cation dependent)
Synonyms CD-MPR, MPR 46, MPR-46, MPR46, SMPR
General protein information
Preferred Names
cation-dependent mannose-6-phosphate receptor
Names
cation-dependent mannose-6-phosphate receptor
Mr 46,000 Man6PR
CD Man-6-P receptor
small mannose 6-phosphate receptor
46-kDa mannose 6-phosphate receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13

Summary This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011].
Disorder

MIM: 154540

mRNA Protein Product Sequence Price Select
NM_001207024, 333440433 NP_001193953, 333440434 cation-dependent mannose-6-phosphate receptor isoform 2 precursor ORF Sequence $250.00
NM_002355, 333440432 NP_002346, 4505061 cation-dependent mannose-6-phosphate receptor isoform 1 precursor ORF Sequence $199.00
XM_005253376, 530399158 XP_005253433, 530399159 cation-dependent mannose-6-phosphate receptor isoform X1 ORF Sequence $300.00
KEGG
hsa04142Lysosome
hsa04145Phagosome
Reactome
REACT_19187Clathrin derived vesicle budding
REACT_19287Lysosome Vesicle Biogenesis
REACT_11123Membrane Trafficking
REACT_11235trans-Golgi Network Vesicle Budding
Homo sapiens (human)M6PRNP_002346.1
Pan troglodytes (chimpanzee)M6PRXP_001138077.1
Macaca mulatta (Rhesus monkey)M6PRXP_001114044.2
Canis lupus familiaris (dog)M6PRXP_005637236.1
Bos taurus (cattle)M6PRNP_786973.1
Mus musculus (house mouse)M6prNP_034879.2
Rattus norvegicus (Norway rat)M6prNP_001007701.1
Rattus norvegicus (Norway rat)LOC100909548XP_003752148.1
Gallus gallus (chicken)M6PRXP_416477.3
Danio rerio (zebrafish)m6prNP_998370.1
Xenopus (Silurana) tropicalis (western clawed frog)m6prNP_001008115.1
Process
IDNameEvidence
GO:0006898receptor-mediated endocytosisTAS
GO:0007165signal transductionTAS
GO:0008333endosome to lysosome transportTAS
GO:0015761mannose transportIEA
Component
IDNameEvidence
GO:0005765lysosomal membraneIEA
GO:0005768endosomeIDA
GO:0005770late endosomeIEA
GO:0005887integral component of plasma membraneTAS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0004888transmembrane signaling receptor activityTAS
GO:0005537mannose bindingIEA
GO:0015578mannose transmembrane transporter activityIEA
GeneCards M6PR
PDB 1JUQ
UniProt P20645
Vega OTTHUMG00000168276
MIM 154540
Ensembl ENSG00000003056
HGNC 6752
HPRD 01106

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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