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MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002358 Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1), mRNA. ORF Sequence $179.22
Peptide Services
Antibody Services
Protein Services


Gene Symbol MAD2L1
Entrez Gene ID 4085
Full Name MAD2 mitotic arrest deficient-like 1 (yeast)
Synonyms HSMAD2, MAD2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q27

Summary MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601467

mRNA Protein Product Sequence Price Select
NM_002358, 194688136 NP_002349, 4505067 mitotic spindle assembly checkpoint protein MAD2A Full Length $421.37
ORF Sequence $179.22
KEGG
hsa04114Oocyte meiosis
hsa05166HTLV-I infection
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
WikiPathways
WP179Cell cycle
Reactome
REACT_21300Mitotic M-M/G1 phases
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_795Amplification of signal from the kinetochores
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_152Cell Cycle, Mitotic
REACT_1538Cell Cycle Checkpoints
REACT_682Mitotic Prometaphase
REACT_910M Phase
REACT_2137Mitotic Spindle Checkpoint
REACT_1072Inactivation of APC/C via direct inhibition of the APC/C complex
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_21279Regulation of mitotic cell cycle
REACT_115566Cell Cycle
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_383DNA Replication
REACT_491Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REACT_1041Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Homo sapiens (human)MAD2L1NP_002349.1
Pan troglodytes (chimpanzee)MAD2L1XP_003310508.1
Macaca mulatta (Rhesus monkey)MAD2L1XP_001097054.2
Canis lupus familiaris (dog)MAD2L1XP_533278.2
Bos taurus (cattle)MAD2L1NP_001178442.1
Mus musculus (house mouse)Mad2l1NP_062372.2
Rattus norvegicus (Norway rat)Mad2l1NP_001100064.1
Gallus gallus (chicken)MAD2L1XP_420629.1
Danio rerio (zebrafish)mad2l1NP_001017739.1
Drosophila melanogaster (fruit fly)mad2NP_647991.1
Caenorhabditis elegansmdf-2NP_001023563.1
Arabidopsis thaliana (thale cress)MAD2NP_189227.1
GeneCards MAD2L1
PDB 2V64, 1KLQ, 3GMH, 2VFX, 2QYF, 1GO4, 1S2H, 1DUJ
UniProt Q13257
MIM 601467
Ensembl ENSG00000164109
HGNC 6763
HPRD 03274

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mitotic spindle assembly checkpoint protein MAD2A
Names
mitotic spindle assembly checkpoint protein MAD2A
MAD2-like protein 1
mitotic arrest deficient 2-like protein 1
mitotic arrest deficient, yeast, homolog-like 1
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1

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