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MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24019 NM_002358 Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu24019C NM_002358 Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol MAD2L1
Entrez Gene ID 4085
Full Name MAD2 mitotic arrest deficient-like 1 (yeast)
Synonyms HSMAD2, MAD2
General protein information
Preferred Names
mitotic spindle assembly checkpoint protein MAD2A
Names
mitotic spindle assembly checkpoint protein MAD2A
MAD2-like protein 1
mitotic arrest deficient 2-like protein 1
mitotic arrest deficient, yeast, homolog-like 1
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q27

Summary MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601467

mRNA Protein Product Sequence Price Select
NM_002358, 194688136 NP_002349, 4505067 mitotic spindle assembly checkpoint protein MAD2A ORF Sequence $159.00
KEGG
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
hsa04114Oocyte meiosis
hsa05166HTLV-I infection
WikiPathways
WP179Cell cycle
Reactome
REACT_1538Cell Cycle Checkpoints
REACT_1041Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
REACT_1072Inactivation of APC/C via direct inhibition of the APC/C complex
REACT_152Cell Cycle, Mitotic
REACT_795Amplification of signal from the kinetochores
REACT_2137Mitotic Spindle Checkpoint
REACT_682Mitotic Prometaphase
REACT_1275Mitotic Anaphase
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_491Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REACT_910M Phase
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_21279Regulation of mitotic cell cycle
REACT_115566Cell Cycle
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_150314Mitotic Metaphase and Anaphase
REACT_150471Separation of Sister Chromatids
Homo sapiens (human)MAD2L1NP_002349.1
Pan troglodytes (chimpanzee)MAD2L1XP_003310508.1
Macaca mulatta (Rhesus monkey)MAD2L1XP_001097054.2
Canis lupus familiaris (dog)LOC476070XP_533278.2
Bos taurus (cattle)MAD2L1NP_001178442.1
Mus musculus (house mouse)Mad2l1NP_062372.2
Rattus norvegicus (Norway rat)Mad2l1NP_001100064.1
Gallus gallus (chicken)MAD2L1NP_001264678.1
Danio rerio (zebrafish)mad2l1NP_001017739.1
Drosophila melanogaster (fruit fly)mad2NP_647991.1
Caenorhabditis elegansmdf-2NP_001023563.1
Arabidopsis thaliana (thale cress)MAD2NP_189227.1
Xenopus (Silurana) tropicalis (western clawed frog)mad2l1NP_001096528.1
Process
IDNameEvidence
GO:0000070mitotic sister chromatid segregationIEA
GO:0000278mitotic cell cycleTAS
GO:0007093mitotic cell cycle checkpointIDA
GO:0007093mitotic cell cycle checkpointIGI
GO:0007094mitotic spindle assembly checkpointTAS
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTAS
GO:0042177negative regulation of protein catabolic processIDA
GO:0043066negative regulation of apoptotic processIMP
GO:0045930negative regulation of mitotic cell cycleIMP
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTAS
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTAS
GO:0060564negative regulation of mitotic anaphase-promoting complex activityIDA
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpointIMP
Component
IDNameEvidence
GO:0000776kinetochoreIDA
GO:0000776kinetochoreIDA
GO:0000777condensed chromosome kinetochoreIEA
GO:0000922spindle poleIEA
GO:0005634nucleusIDA
GO:0005643nuclear poreIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0048471perinuclear region of cytoplasmIDA
GO:0072686mitotic spindleIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIPI
GeneCards MAD2L1
UniProt Q13257
MIM 601467
HGNC 6763
HPRD 03274

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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