Sequence in raw or FASTA format:
MAG myelin associated glycoprotein [
Homo sapiens (human)]
Gene Symbol MAG
Entrez Gene ID
Full Name myelin associated glycoprotein
Synonyms GMA, S-MAG, SIGLEC-4A, SIGLEC4A
General protein information
sialic acid binding Ig-like lectin 4A
sialic acid-binding immunoglobulin-like lectin 4A
Gene Type protein-coding
Homo sapiens (human)
Chromosome:19 Map Location:19q13.1
Summary The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010].
Pathway Interaction Database
Related articles in PubMed Loss of myelin-associated glycoprotein in kearns-sayre syndrome. Lax NZ, et al. Arch Neurol, 2012 Apr. PMID 22491194. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611. Non-anti-MAG DADS neuropathy as a variant of CIDP: clinical, electrophysiological, laboratory features and response to treatment in 10 cases. Larue S, et al. Eur J Neurol, 2011 Jun. PMID 21199182. N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy. Piccinini M, et al. Brain Pathol, 2010 Mar. PMID 19725832. See all (46) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Primary mitochondrial respiratory chain defects affecting the white matter, and unrelated to inflammation, are associated with MAG loss and central nervous system demyelination.
Title: Loss of myelin-associated glycoprotein in kearns-sayre syndrome.
Distal acquired demyelinating symmetric neuropathy without anti-MAG antibodies is more likely to be considered a variant of chronic inflammatory demyelinating polyradiculoneuropathy, including a hematological or immunological condition.
Title: Non-anti-MAG DADS neuropathy as a variant of CIDP: clinical, electrophysiological, laboratory features and response to treatment in 10 cases.
polysialylated NCAM persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy
Title: N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy.
ELISA is more sensitive than Western blot to diagnose anti-myelin-associated glycoprotein related polyneuropathy, although a positive serology may be found in other forms of polyneuropathy as well.
Title: Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy.
Taken together, these findings suggest that in anti-MAG neuropathy patients, IgM deposits are entrapped within cutaneous perineurium-ensheathed nerve bundles where they accumulate in the endoneurial space.
Title: Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration.
RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation.
Title: A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
In our patient, propriospinal myoclonus was associated with anti-MAG polyneuropathy, but the causal relationship remains unclear.
Title: Axial myoclonus in paraproteinemic polyneuropathy.
This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population.
Title: A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia.
Twenty of 46 patients with IgM amyloidosis (7 with and 13 without polyneuropathy) had elevation of anti-MAG or SGPG by enzyme-linked immunosorbent assay
Title: Antibodies to myelin-associated glycoprotein (anti-Mag) in IgM amyloidosis may influence expression of neuropathy in rare patients.
Expression of MAG, CNP and OLIG2 did not differ between patients with schizophrenia and controls in the grey or white matter
Title: Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.
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