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MAK male germ cell-associated kinase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001242385 Homo sapiens male germ cell-associated kinase (MAK), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001242957 Homo sapiens male germ cell-associated kinase (MAK), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_005906 Homo sapiens male germ cell-associated kinase (MAK), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006715098 PREDICTED: Homo sapiens male germ cell-associated kinase (MAK), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol MAK
Entrez Gene ID 4117
Full Name male germ cell-associated kinase
Synonyms RP62, dJ417M14.2
General protein information
Preferred Names
serine/threonine-protein kinase MAK
Names
serine/threonine-protein kinase MAK
serine/threonine protein kinase MAK
male germ cell-associated kinase retinal-enriched isoform
NP_001229314.1
NP_001229886.1
NP_005897.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p24

Summary The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Disorder

MIM: 154235

mRNA Protein Product Sequence Price Select
NM_001242385, 334724435 NP_001229314, 334724436 serine/threonine-protein kinase MAK isoform 2 ORF Sequence $700.00
NM_001242957, 339639607 NP_001229886, 339639608 serine/threonine-protein kinase MAK isoform 3 ORF Sequence $700.00
NM_005906, 334724434 NP_005897, 11496279 serine/threonine-protein kinase MAK isoform 1 ORF Sequence $700.00
XM_006715098, 578811690 XP_006715161, 578811691 serine/threonine-protein kinase MAK isoform X1 ORF Sequence $550.00
Pathway Interaction Database
ar_pathwayCoregulation of Androgen receptor activity
Homo sapiens (human)MAKNP_001229886.1
Pan troglodytes (chimpanzee)MAKXP_003950767.1
Macaca mulatta (Rhesus monkey)MAKXP_001088297.1
Canis lupus familiaris (dog)MAKXP_003434222.1
Bos taurus (cattle)MAKNP_001039880.2
Mus musculus (house mouse)MakNP_001139275.1
Rattus norvegicus (Norway rat)MakNP_037268.1
Gallus gallus (chicken)MAKXP_418948.3
Danio rerio (zebrafish)makNP_956240.1
Arabidopsis thaliana (thale cress)MHKNP_001190712.1
Xenopus (Silurana) tropicalis (western clawed frog)makNP_001072807.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006468protein phosphorylationIDA
GO:0007275multicellular organismal developmentIEA
GO:0007283spermatogenesisNAS
GO:0030154cell differentiationIEA
GO:0045494photoreceptor cell maintenanceISS
GO:0046777protein autophosphorylationIMP
GO:0051726regulation of cell cycleIEA
Component
IDNameEvidence
GO:0001750photoreceptor outer segmentISS
GO:0001917photoreceptor inner segmentIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIEA
GO:0005813centrosomeIDA
GO:0030496midbodyIDA
GO:0072686mitotic spindleIDA
Function
IDNameEvidence
GO:0003713transcription coactivator activityIDA
GO:0004672protein kinase activityNAS
GO:0004693cyclin-dependent protein serine/threonine kinase activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GeneCards MAK
UniProt P20794, F8VBW7
Vega OTTHUMG00000014247
MIM 154235
Ensembl ENSG00000111837
HGNC 6816
HPRD 01101

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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