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MAL mal, T-cell differentiation protein [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu15772 NM_022439 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant c, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu15962 NM_022440 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant d, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu15983 NM_002371 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant a, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16029 NM_022438 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant b, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu15772C NM_022439 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant c, mRNA. Customized vector On-demand 7-9 $209.00
OHu15962C NM_022440 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant d, mRNA. Customized vector On-demand 7-9 $209.00
OHu15983C NM_002371 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant a, mRNA. Customized vector In-stock 5-7 $149.00
OHu16029C NM_022438 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant b, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol MAL
Entrez Gene ID 4118
Full Name mal, T-cell differentiation protein
Synonyms
General protein information
Preferred Names
myelin and lymphocyte protein
Names
myelin and lymphocyte protein
T-lymphocyte maturation-associated protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q11.1

Summary The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012].
Disorder

MIM: 188860

mRNA Protein Product Sequence Price Select
NM_002371, 386781923 NP_002362, 4505091 myelin and lymphocyte protein isoform a ORF Sequence $99.00
NM_022438, 386781930 NP_071883, 12408661 myelin and lymphocyte protein isoform b ORF Sequence $150.00
NM_022439, 386781937 NP_071884, 12408663 myelin and lymphocyte protein isoform c ORF Sequence $150.00
NM_022440, 386781942 NP_071885, 12408665 myelin and lymphocyte protein isoform d ORF Sequence $150.00
Homo sapiens (human)MALNP_002362.1
Pan troglodytes (chimpanzee)MALXP_003949891.1
Macaca mulatta (Rhesus monkey)MALXP_001095645.2
Canis lupus familiaris (dog)MALNP_001003253.1
Bos taurus (cattle)MALNP_001068896.1
Mus musculus (house mouse)MalNP_034892.1
Rattus norvegicus (Norway rat)MalNP_036930.1
Gallus gallus (chicken)MALNP_001186320.1
Danio rerio (zebrafish)malNP_001017686.1
Danio rerio (zebrafish)zgc:158773NP_001075880.1
Danio rerio (zebrafish)zgc:153665NP_001070931.1
Xenopus (Silurana) tropicalis (western clawed frog)malNP_001006929.1
Process
IDNameEvidence
GO:0001766membrane raft polarizationTAS
GO:0006915apoptotic processNAS
GO:0007417central nervous system developmentTAS
GO:0030154cell differentiationTAS
GO:0042552myelinationNAS
GO:0042552myelinationTAS
GO:0045176apical protein localizationTAS
GO:0055085transmembrane transportTAS
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA
Component
IDNameEvidence
GO:0005768endosomeTAS
GO:0005783endoplasmic reticulumIDA
GO:0005887integral component of plasma membraneTAS
GO:0016324apical plasma membraneTAS
GO:0019898extrinsic component of membraneIEA
GO:0045121membrane raftIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0008289lipid bindingTAS
GO:0015267channel activityTAS
GO:0016505peptidase activator activity involved in apoptotic processNAS
GO:0019911structural constituent of myelin sheathIDA
GeneCards MAL
UniProt P21145
Vega OTTHUMG00000132011
MIM 188860
Ensembl ENSG00000172005
HGNC 6817
HPRD 01789

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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