• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


MAN2B1 mannosidase, alpha, class 2B, member 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000528 Homo sapiens mannosidase, alpha, class 2B, member 1 (MAN2B1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16
NM_001173498 Homo sapiens mannosidase, alpha, class 2B, member 1 (MAN2B1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol MAN2B1
Entrez Gene ID 4125
Full Name mannosidase, alpha, class 2B, member 1
Synonyms LAMAN, MANB
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].

MIM: 609458

Mannosidosis, alpha-, types I and II, 248500 (3)

mRNA Protein Product Sequence Price Select
NM_000528, 187828659 NP_000519, 51873064 lysosomal alpha-mannosidase isoform 1 precursor ORF Sequence $999.00
NM_001173498, 291045219 NP_001166969, 291045220 lysosomal alpha-mannosidase isoform 2 precursor ORF Sequence $1500.00
hsa00511Other glycan degradation
Homo sapiens (human)MAN2B1NP_001166969.1
Pan troglodytes (chimpanzee)MAN2B1XP_003316198.2
Macaca mulatta (Rhesus monkey)LOC716173XP_002801133.1
Canis lupus familiaris (dog)MAN2B1XP_542048.3
Bos taurus (cattle)MAN2B1NP_776986.2
Mus musculus (house mouse)Man2b1NP_034894.2
Rattus norvegicus (Norway rat)Man2b1NP_955436.1
Danio rerio (zebrafish)zgc:110815NP_001014354.1
Drosophila melanogaster (fruit fly)CG6206NP_609408.1
Caenorhabditis elegansaman-1NP_508811.1
Arabidopsis thaliana (thale cress)AT5G13980NP_851037.2
GeneCards MAN2B1
UniProt A8K6A7, O00754, G5E928
MIM 609458
Ensembl ENSG00000104774
HGNC 6826
HPRD 02007

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
lysosomal alpha-mannosidase
lysosomal alpha-mannosidase
mannosidase alpha-B
mannosidase, alpha B, lysosomal
lysosomal acid alpha-mannosidase


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Learn more about the GenEZ ORF Cloning Service.