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MAOA monoamine oxidase A [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu14879 NM_001270458 Homo sapiens monoamine oxidase A (MAOA), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $149.00
OHu21311 NM_000240 Homo sapiens monoamine oxidase A (MAOA), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $149.00
OHu14879C NM_001270458 Homo sapiens monoamine oxidase A (MAOA), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu21311C NM_000240 Homo sapiens monoamine oxidase A (MAOA), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol MAOA
Entrez Gene ID 4128
Full Name monoamine oxidase A
Synonyms MAO-A
General protein information
Preferred Names
amine oxidase [flavin-containing] A
Names
amine oxidase [flavin-containing] A
monoamine oxidase type A
NP_000231.1
NP_001257387.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.3

Summary This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
Disorder

MIM: 309850

Brunner syndrome, 300615 (3)

mRNA Protein Product Sequence Price Select
NM_000240, 395132502 NP_000231, 4557735 amine oxidase [flavin-containing] A isoform 1 ORF Sequence $360.00
NM_001270458, 395132503 NP_001257387, 395132504 amine oxidase [flavin-containing] A isoform 2 ORF Sequence $269.00
KEGG
hsa00340Histidine metabolism
hsa00330Arginine and proline metabolism
hsa00350Tyrosine metabolism
hsa00260Glycine, serine and threonine metabolism
hsa00360Phenylalanine metabolism
hsa00380Tryptophan metabolism
hsa00982Drug metabolism - cytochrome P450
hsa_M00135GABA biosynthesis, eukaryotes, putrescine => GABA
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
WikiPathways
WP550Biogenic Amine Synthesis
WP706SIDS Susceptibility Pathways
WP408Oxidative Stress
WP2436Dopamine metabolism
WP1455Serotonin Transporter Activity
BIOCYC
META_PWY6666-2dopamine degradation
META_PWY-6313serotonin degradation
HUMAN_PWY6666-2dopamine degradation
HUMAN_PWY-6342noradrenaline and adrenaline degradation
HUMAN_PWY-6318phenylalanine degradation IV (mammalian, via side chain)
HUMAN_PWY-6307tryptophan degradation X (mammalian, via tryptamine)
HUMAN_PWY-6402superpathway of melatonin degradation
HUMAN_PWY-0putrescine degradation III
HUMAN_PWY-6313serotonin degradation
HUMAN_PWY-6399melatonin degradation II
Reactome
REACT_13433Biological oxidations
REACT_416Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
REACT_13705Phase 1 - Functionalization of compounds
REACT_1875Amine Oxidase reactions
REACT_15514Dopamine clearance from the synaptic cleft
REACT_15511Enzymatic degradation of Dopamine by monoamine oxidase
REACT_15418Norepinephrine Neurotransmitter Release Cycle
REACT_13583Neurotransmitter Clearance In The Synaptic Cleft
REACT_13723Neurotransmitter Release Cycle
REACT_13477Transmission across Chemical Synapses
REACT_15391Serotonin clearance from the synaptic cleft
REACT_15548Enzymatic degradation of dopamine by COMT
REACT_13685Neuronal System
REACT_15532Metabolism of serotonin
REACT_111217Metabolism
Homo sapiens (human)MAOANP_000231.1
Pan troglodytes (chimpanzee)LOC743285XP_003317484.1
Canis lupus familiaris (dog)MAOANP_001002969.1
Bos taurus (cattle)MAOANP_851357.2
Mus musculus (house mouse)MaoaNP_776101.3
Rattus norvegicus (Norway rat)MaoaNP_387502.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100495198XP_002932844.2
Process
IDNameEvidence
GO:0006576cellular biogenic amine metabolic processTAS
GO:0006805xenobiotic metabolic processTAS
GO:0007268synaptic transmissionTAS
GO:0007269neurotransmitter secretionTAS
GO:0042135neurotransmitter catabolic processIEA
GO:0042136neurotransmitter biosynthetic processTAS
GO:0042420dopamine catabolic processIEA
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005741mitochondrial outer membraneTAS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0008131primary amine oxidase activityTAS
GeneCards MAOA
UniProt Q49A63, P21397, Q53YE7
MIM 309850
HGNC 6833
HPRD 02400

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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