MAOA monoamine oxidase A [Homo sapiens (human)]
| Gene Symbol | MAOA |
| Entrez Gene ID | 4128 |
| Full Name | monoamine oxidase A |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
X Xp11.3 |
| Summary | This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. The gene is adjacent to a related gene on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. [provided by RefSeq]. |
| Disorder | MIM: 309850 Brunner syndrome, 300615 (3) |
| mRNA | NM_000240, 33469954 |
| Protein | NP_000231, 4557735 |
| Product | amine oxidase [flavin-containing] A |
| RefSeq Status | REVIEWED |
| hsa00380 | Tryptophan metabolism |
| hsa00260 | Glycine, serine and threonine metabolism |
| hsa00982 | Drug metabolism - cytochrome P450 |
| hsa00360 | Phenylalanine metabolism |
| hsa00340 | Histidine metabolism |
| hsa00350 | Tyrosine metabolism |
| hsa01100 | Metabolic pathways |
| hsa00330 | Arginine and proline metabolism |
WikiPathways
| WP550 | Biogenic Amine Synthesis |
| WP408 | Oxidative Stress |
| WP706 | SIDS Susceptibility Pathways |
BIOCYC
| META_PWY-6313 | serotonin degradation |
| META_PWY6666-2 | dopamine degradation |
Reactome
| REACT_15418 | Norepinephrine Neurotransmitter Release Cycle |
| REACT_13583 | Neurotransmitter Clearance In The Synaptic Cleft |
| REACT_15532 | Metabolism of serotonin |
| REACT_13723 | Neurotransmitter Release Cycle |
| REACT_13705 | Phase 1 - Functionalization of compounds |
| REACT_15548 | Enzymatic degradation of dopamine by COMT |
| REACT_15391 | Serotonin clearance from the synaptic cleft |
| REACT_13433 | Biological oxidations |
| REACT_1875 | Amine Oxidase reactions |
| REACT_13477 | Transmission across Chemical Synapses |
| REACT_416 | Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 |
| REACT_13685 | Synaptic Transmission |
| REACT_15514 | Dopamine clearance from the synaptic cleft |
| REACT_15511 | Enzymatic degradation of Dopamine by monoamine oxidase |
| Homo sapiens (human) | MAOA | NP_000231.1 |
| Pan troglodytes (chimpanzee) | MAOA | XP_001139533.1 |
| Canis lupus familiaris (dog) | MAOA | XP_855548.1 |
| Bos taurus (cattle) | MAOA | NP_851357.2 |
| Mus musculus (house mouse) | Maoa | NP_776101.2 |
| Rattus norvegicus (Norway rat) | Maoa | XP_343765.1 |
| ID | Name | Evidence |
| GO:0006576 | cellular biogenic amine metabolic process | TAS |
| GO:0006584 | catecholamine metabolic process | IEA |
| GO:0006805 | xenobiotic metabolic process | TAS |
| GO:0007268 | synaptic transmission | TAS |
| GO:0007269 | neurotransmitter secretion | TAS |
| GO:0007610 | behavior | TAS |
| GO:0042135 | neurotransmitter catabolic process | IEA |
| GO:0042136 | neurotransmitter biosynthetic process | TAS |
| GO:0042420 | dopamine catabolic process | IEA |
Component
| ID | Name | Evidence |
| GO:0005739 | mitochondrion | IEA |
| GO:0005741 | mitochondrial outer membrane | EXP |
| GO:0005741 | mitochondrial outer membrane | TAS |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0008131 | primary amine oxidase activity | EXP |
| GO:0008131 | primary amine oxidase activity | TAS |
| GO:0016491 | oxidoreductase activity | IEA |
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