Sequence in raw or FASTA format:
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 [Homo sapiens (human)]
| Gene Symbol | CHST6 |
| Entrez Gene ID | 4166 |
| Full Name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
| Synonyms | MCDC1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
16 16q22 |
| Summary | The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq]. |
| Disorder | MIM: 605294 Macular corneal dystrophy, 217800 (3) |
| mRNA | NM_021615, 108936954 |
| Protein | NP_067628, 11055976 |
| Product | carbohydrate sulfotransferase 6 |
| RefSeq Status | REVIEWED |
| hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate |
| Homo sapiens (human) | CHST6 | NP_067628.1 |
| Pan troglodytes (chimpanzee) | CHST6 | XP_001141466.1 |
| Canis lupus familiaris (dog) | CHST6 | XP_546827.1 |
| Bos taurus (cattle) | CHST6 | XP_580513.2 |
| Mus musculus (house mouse) | Chst5 | NP_064334.1 |
| Rattus norvegicus (Norway rat) | Chst5 | XP_226482.3 |
| Gallus gallus (chicken) | CHST6 | XP_001232705.1 |
| Danio rerio (zebrafish) | zgc:194879 | NP_001124093.1 |
| ID | Name | Evidence |
| GO:0005975 | carbohydrate metabolic process | IEA |
| GO:0006044 | N-acetylglucosamine metabolic process | IC |
| GO:0006044 | N-acetylglucosamine metabolic process | IDA |
| GO:0006790 | sulfur compound metabolic process | IDA |
| GO:0018146 | keratan sulfate biosynthetic process | IDA |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | IEA |
| GO:0005794 | Golgi apparatus | TAS |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity | IDA |
| GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity | TAS |
| GO:0016740 | transferase activity | IEA |
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