• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


MYH7 myosin, heavy chain 7, cardiac muscle, beta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28301 NM_000257 Homo sapiens myosin, heavy chain 7, cardiac muscle, beta (MYH7), mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu47715 XM_005267697 PREDICTED: Homo sapiens myosin, heavy chain 7, cardiac muscle, beta (MYH7), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu28301C NM_000257 Homo sapiens myosin, heavy chain 7, cardiac muscle, beta (MYH7), mRNA. Customized vector On-demand 30 $2699.00
OHu47715C XM_005267697 PREDICTED: Homo sapiens myosin, heavy chain 7, cardiac muscle, beta (MYH7), transcript variant X2, mRNA. Customized vector On-demand 25 $1699.00

*Business Day

Related Services

Gene Symbol MYH7
Entrez Gene ID 4625
Full Name myosin, heavy chain 7, cardiac muscle, beta
Synonyms CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM
General protein information
Preferred Names
myosin-7
Names
myosin-7
myHC-beta
myhc-slow
myopathy, distal 1
myosin heavy chain 7
beta-myosin heavy chain
myosin heavy chain (AA 1-96)
myosin heavy chain slow isoform
rhabdomyosarcoma antigen MU-RMS-40.7A
myosin heavy chain, cardiac muscle beta isoform
myosin, heavy polypeptide 7, cardiac muscle, beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q12

Summary Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 160760

Cardiomyopathy, familial hypertrophic, 1, 192600 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_000257, 657940851 NP_000248, 115496169 myosin-7 ORF Sequence $2500.00
XM_005267697, 578825827 XP_005267754, 530403850 myosin-7 isoform X2 ORF Sequence $1500.00
KEGG
hsa04530Tight junction
hsa05416Viral myocarditis
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04261Adrenergic signaling in cardiomyocytes
hsa04022cGMP-PKG signaling pathway
Reactome
REACT_11123Membrane Trafficking
REACT_147867Translocation of GLUT4 to the plasma membrane
Homo sapiens (human)MYH7NP_000248.2
Pan troglodytes (chimpanzee)MYH7XP_001150786.3
Canis lupus familiaris (dog)MYH7NP_001107183.1
Bos taurus (cattle)MYH7NP_777152.1
Mus musculus (house mouse)Myh7NP_542766.1
Rattus norvegicus (Norway rat)Myh7NP_058936.1
Gallus gallus (chicken)MYH7NP_001001302.1
Danio rerio (zebrafish)vmhcNP_001106204.1
Danio rerio (zebrafish)smyhc1NP_001018343.1
Danio rerio (zebrafish)smyhc3NP_001129995.1
Danio rerio (zebrafish)vmhclNP_001070932.2
Danio rerio (zebrafish)si:ch211-24n20.3XP_001923213.1
Danio rerio (zebrafish)smyhc2NP_001096096.2
Danio rerio (zebrafish)LOC100329670XP_002666777.2
Danio rerio (zebrafish)LOC100329748XP_002666778.1
Danio rerio (zebrafish)LOC567740XP_696132.3
Danio rerio (zebrafish)LOC100329813XP_002666779.1
Drosophila melanogaster (fruit fly)MhcNP_001246049.1
Xenopus (Silurana) tropicalis (western clawed frog)myh7XP_002939061.1
Process
IDNameEvidence
GO:0002026regulation of the force of heart contractionIDA
GO:0002027regulation of heart rateIDA
GO:0006200ATP catabolic processIDA
GO:0006936muscle contractionIDA
GO:0006936muscle contractionTAS
GO:0006941striated muscle contractionIDA
GO:0007512adult heart developmentIMP
GO:0030049muscle filament slidingIMP
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
Component
IDNameEvidence
GO:0001725stress fiberIEA
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005859muscle myosin complexTAS
GO:0005925focal adhesionIDA
GO:0016459myosin complexTAS
GO:0030017sarcomereTAS
GO:0030018Z discIEA
GO:0032982myosin filamentIDA
Function
IDNameEvidence
GO:0000146microfilament motor activityIDA
GO:0000146microfilament motor activityNAS
GO:0003779actin bindingIEA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIEA
GO:0016887ATPase activityIDA
GO:0030898actin-dependent ATPase activityIMP
GeneCards MYH7
PDB 2FXM, 2FXO, 4P7H, 3DTP, 1IK2, 4DB1
UniProt P12883
Vega OTTHUMG00000028755
MIM 160760
Ensembl ENSG00000092054
HGNC 7577
HPRD 01175

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.