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MYH7 myosin, heavy chain 7, cardiac muscle, beta [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000257 Homo sapiens myosin, heavy chain 7, cardiac muscle, beta (MYH7), mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol MYH7
Entrez Gene ID 4625
Full Name myosin, heavy chain 7, cardiac muscle, beta
Synonyms CMD1S, CMH1, DKFZp451F047, MGC138376, MGC138378, MPD1, MYHCB, SPMD, SPMM
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008].

MIM: 160760

Cardiomyopathy, familial hypertrophic, 1, 192600 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_000257, 115496168 NP_000248, 115496169 myosin-7 ORF Sequence $2500.00
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04530Tight junction
hsa04260Cardiac muscle contraction
hsa05416Viral myocarditis
hsa05414Dilated cardiomyopathy
Homo sapiens (human)MYH7NP_000248.2
Pan troglodytes (chimpanzee)MYH7XP_001150786.3
Canis lupus familiaris (dog)MYH7NP_001107183.1
Bos taurus (cattle)MYH7NP_777152.1
Mus musculus (house mouse)Myh7NP_542766.1
Rattus norvegicus (Norway rat)Myh7NP_058936.1
Gallus gallus (chicken)MYH7NP_001001302.1
Danio rerio (zebrafish)smyhc2NP_001096096.2
Danio rerio (zebrafish)smyhc1NP_001018343.1
Danio rerio (zebrafish)LOC567740XP_696132.3
Danio rerio (zebrafish)LOC100329813XP_002666779.1
Danio rerio (zebrafish)LOC100001366XP_001923213.1
Danio rerio (zebrafish)LOC100329748XP_002666778.1
Danio rerio (zebrafish)vmhclNP_001070932.2
Danio rerio (zebrafish)vmhcNP_001106204.1
Danio rerio (zebrafish)LOC100329670XP_002666777.1
Danio rerio (zebrafish)smyhc3NP_001129995.1
GeneCards MYH7
PDB 2FXM, 2FXO, 3DTP, 1IK2, 4DB1
UniProt P12883
MIM 160760
Ensembl ENSG00000092054
HGNC 7577
HPRD 01175

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
myopathy, distal 1
myosin heavy chain 7
beta-myosin heavy chain
myosin heavy chain (AA 1-96)
myosin heavy chain slow isoform
rhabdomyosarcoma antigen MU-RMS-40.7A
myosin heavy chain, cardiac muscle beta isoform
myosin, heavy polypeptide 7, cardiac muscle, beta


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