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Sequence in raw or FASTA format:


Blast Method:


MYL2 myosin, light chain 2, regulatory, cardiac, slow [Homo sapiens (human)]

RefSeq Accession Definition Services Price Order
NM_000432 Homo sapiens myosin, light chain 2, regulatory, cardiac, slow (MYL2), mRNA. ORF Sequence $159.00
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Gene Symbol MYL2
Entrez Gene ID 4633
Full Name myosin, light chain 2, regulatory, cardiac, slow
Synonyms CMH10, DKFZp779C0562, MLC2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].

MIM: 160781

Cardiomyopathy, familial hypertrophic, 10, 608758 (3)

mRNA Protein Product Sequence Price Select
NM_000432, 190358510 NP_000423, 94981553 myosin regulatory light chain 2, ventricular/cardiac muscle isoform Full Length $247.95
ORF Sequence $159.00
hsa04530Tight junction
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton
hsa04260Cardiac muscle contraction
WP383Striated Muscle Contraction
WP289Myometrial Relaxation and Contraction Pathways
Pathway Interaction Database
ecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
rhoa_pathwayRhoA signaling pathway
cdc42_pathwayCDC42 signaling events
ncadherinpathwayN-cadherin signaling events
REACT_17044Muscle contraction
REACT_16969Striated Muscle Contraction
Homo sapiens (human)MYL2NP_000423.2
Pan troglodytes (chimpanzee)MYL2XP_001144828.2
Macaca mulatta (Rhesus monkey)MYL2XP_001100796.1
Canis lupus familiaris (dog)MYL2NP_001003069.1
Bos taurus (cattle)MYL2NP_001030197.1
Mus musculus (house mouse)Myl2NP_034991.3
Rattus norvegicus (Norway rat)Myl2NP_001030329.1
Gallus gallus (chicken)MYL2XP_415166.1
Danio rerio (zebrafish)myl2bNP_001035134.1
Danio rerio (zebrafish)LOC100537244XP_003198611.1
GeneCards MYL2
UniProt Q6IB42, P10916
MIM 160781
Ensembl ENSG00000111245
HGNC 7583
HPRD 01181

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
RLC of myosin
myosin light chain 2
regulatory light chain of myosin
cardiac ventricular myosin light chain 2
slow cardiac myosin regulatory light chain 2
myosin, light polypeptide 2, regulatory, cardiac, slow


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