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MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000258 Homo sapiens myosin, light chain 3, alkali; ventricular, skeletal, slow (MYL3), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol MYL3
Entrez Gene ID 4634
Full Name myosin, light chain 3, alkali; ventricular, skeletal, slow
Synonyms CMH8, MLC1SB, MLC1V, VLC1
General protein information
Preferred Names
myosin light chain 3
Names
myosin light chain 3
CMLC1
cardiac myosin light chain 1
ventricular/slow twitch myosin alkali light chain
myosin light chain 1, slow-twitch muscle B/ventricular isoform
myosin, light polypeptide 3, alkali; ventricular, skeletal, slow
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.3-p21.2

Summary MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 160790

Cardiomyopathy, familial hypertrophic, 8, 608751 (3)

mRNA Protein Product Sequence Price Select
NM_000258, 115527085 NP_000249, 4557777 myosin light chain 3 ORF Sequence $159.00
KEGG
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04261Adrenergic signaling in cardiomyocytes
WikiPathways
WP51Regulation of Actin Cytoskeleton
WP383Striated Muscle Contraction
Reactome
REACT_16969Striated Muscle Contraction
REACT_17044Muscle contraction
Homo sapiens (human)MYL3NP_000249.1
Pan troglodytes (chimpanzee)LOC460327XP_003309811.2
Macaca mulatta (Rhesus monkey)MYL3XP_001113910.1
Canis lupus familiaris (dog)MYL3XP_005632679.1
Bos taurus (cattle)MYL3NP_001069969.2
Mus musculus (house mouse)Myl3NP_034989.1
Rattus norvegicus (Norway rat)Myl3NP_036738.1
Gallus gallus (chicken)MYL3NP_990490.1
Danio rerio (zebrafish)zgc:66286NP_956810.1
Xenopus (Silurana) tropicalis (western clawed frog)myl3NP_989012.1
Process
IDNameEvidence
GO:0002026regulation of the force of heart contractionIMP
GO:0006942regulation of striated muscle contractionIMP
GO:0007519skeletal muscle tissue developmentIEA
GO:0008152metabolic processIEA
GO:0030049muscle filament slidingTAS
GO:0032781positive regulation of ATPase activityISS
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
GO:0060048cardiac muscle contractionIMP
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005859muscle myosin complexTAS
GO:0030017sarcomereTAS
GO:0031672A bandIDA
GO:0031674I bandIDA
Function
IDNameEvidence
GO:0003774motor activityIEA
GO:0003785actin monomer bindingIDA
GO:0005509calcium ion bindingIEA
GO:0008307structural constituent of muscleTAS
GO:0032038myosin II heavy chain bindingNAS
GeneCards MYL3
UniProt P08590
Vega OTTHUMG00000133516
MIM 160790
Ensembl ENSG00000160808
HGNC 7584
HPRD 01183

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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