MYL4 myosin, light chain 4, alkali; atrial, embryonic [Homo sapiens (human)]
| Gene Symbol | MYL4 |
| Entrez Gene ID | 4635 |
| Full Name | myosin, light chain 4, alkali; atrial, embryonic |
| Synonyms | ALC1, AMLC, GT1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q21-qter |
| Summary | Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 160770 |
| mRNA | NM_001002841, 50845427 |
| Protein | NP_001002841, 50845428 |
| Product | myosin light chain 4 |
| RefSeq Status | REVIEWED |
| mRNA | NM_002476, 17921996 |
| Protein | NP_002467, 4557038 |
| Product | myosin light chain 4 |
| RefSeq Status | REVIEWED |
| WP383 | Striated Muscle Contraction |
| WP289 | Myometrial Relaxation and Contraction Pathways |
Reactome
| REACT_16969 | Striated Muscle Contraction |
| REACT_17044 | Muscle contraction |
| Homo sapiens (human) | MYL4 | NP_001002841.1 |
| Pan troglodytes (chimpanzee) | MYL4 | XP_511623.1 |
| Canis lupus familiaris (dog) | MYL4 | XP_537609.1 |
| Bos taurus (cattle) | MYL4 | NP_001068617.1 |
| Mus musculus (house mouse) | Myl4 | NP_034988.2 |
| Gallus gallus (chicken) | MYL4 | NP_990810.1 |
| Danio rerio (zebrafish) | cmlc1 | NP_571767.1 |
| ID | Name | Evidence |
| GO:0002026 | regulation of the force of heart contraction | IMP |
| GO:0007517 | muscle organ development | NAS |
| GO:0030049 | muscle filament sliding | TAS |
| GO:0032781 | positive regulation of ATPase activity | IMP |
| GO:0060048 | cardiac muscle contraction | IMP |
Component
| ID | Name | Evidence |
| GO:0005829 | cytosol | TAS |
| GO:0005859 | muscle myosin complex | NAS |
| GO:0016459 | myosin complex | IEA |
| GO:0031672 | A band | IMP |
Function
| ID | Name | Evidence |
| GO:0003785 | actin monomer binding | IDA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0008307 | structural constituent of muscle | NAS |
| GO:0032038 | myosin II heavy chain binding | NAS |
| GO:0051015 | actin filament binding | IMP |
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