NFE2L1 nuclear factor (erythroid-derived 2)-like 1 [Homo sapiens (human)]
| Gene Symbol | NFE2L1 |
| Entrez Gene ID | 4779 |
| Full Name | nuclear factor (erythroid-derived 2)-like 1 |
| Synonyms | FLJ00380, LCR-F1, NRF1, TCF11 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q21.3 |
| Summary | This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. [provided by RefSeq]. |
| Disorder | MIM: 163260 |
| mRNA | NM_003204, 189181670 |
| Protein | NP_003195, 4505379 |
| Product | nuclear factor erythroid 2-related factor 1 |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | NFE2L1 | NP_003195.1 |
| Pan troglodytes (chimpanzee) | NFE2L1 | XP_001173202.1 |
| Canis lupus familiaris (dog) | NFE2L1 | XP_864626.1 |
| Bos taurus (cattle) | NFE2L1 | NP_001095985.1 |
| Mus musculus (house mouse) | Nfe2l1 | NP_032712.2 |
| Rattus norvegicus (Norway rat) | Nfe2l1 | XP_340887.2 |
| Gallus gallus (chicken) | NFE2L1 | NP_001025927.1 |
| Danio rerio (zebrafish) | LOC558772 | XP_001920265.2 |
| ID | Name | Evidence |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS |
| GO:0006783 | heme biosynthetic process | TAS |
| GO:0006954 | inflammatory response | TAS |
| GO:0009653 | anatomical structure morphogenesis | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
Function
| ID | Name | Evidence |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GO:0003712 | transcription cofactor activity | TAS |
| GO:0043565 | sequence-specific DNA binding | IEA |
| GO:0046983 | protein dimerization activity | IEA |
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