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NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_001007792 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 3, mRNA. Full Length $748.49
ORF Sequence $662.07
NM_002529 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 2, mRNA. Full Length $772.27
ORF Sequence $693.39
NM_001012331 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 1, mRNA. Full Length $767.63
ORF Sequence $688.17


Gene Symbol NTRK1
Entrez Gene ID 4914
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms DKFZp781I14186, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q21-q22
Summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq].
Disorder

MIM: 191315

Insensitivity to pain, congenital, with anhidrosis, 256800 (3);
mRNA NM_001007792, 56118209
Protein NP_001007793, 56118210
Product high affinity nerve growth factor receptor isoform 3
RefSeq Status REVIEWED
mRNA NM_002529, 59889556
Protein NP_002520, 4585712
Product high affinity nerve growth factor receptor isoform 2
RefSeq Status REVIEWED
mRNA NM_001012331, 59889557
Protein NP_001012331, 59889558
Product high affinity nerve growth factor receptor isoform 1
RefSeq Status REVIEWED
KEGG
hsa04722Neurotrophin signaling pathway
hsa05216Thyroid cancer
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa04210Apoptosis
WikiPathways
WP382MAPK signaling pathway
Pathway Interaction Database
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
Reactome
REACT_12049Signalling to STAT3
REACT_12033Signalling to RAS
REACT_12002ARMS-mediated activation
REACT_12435Retrograde neurotrophin signalling
REACT_11046NGF-independant TRKA activation
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_11064Activation of TRKA receptors
REACT_12077Signalling to p38 via RIT and RIN
REACT_12076Frs2-mediated activation
REACT_12079PLC-gamma1 signalling
REACT_12464PI3K/AKT signalling
REACT_12005Prolonged ERK activation events
REACT_11060TRKA activation by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
Homo sapiens (human)NTRK1NP_002520.2
Pan troglodytes (chimpanzee)NTRK1XP_001145942.1
Canis lupus familiaris (dog)NTRK1XP_547525.2
Bos taurus (cattle)NTRK1XP_613650.3
Mus musculus (house mouse)Ntrk1XP_283871.1
Rattus norvegicus (Norway rat)Ntrk1NP_067600.1
Gallus gallus (chicken)NTRK1NP_990709.1
Danio rerio (zebrafish)ntrk1XP_697246.4
Process
IDNameEvidence
GO:0000186activation of MAPKK activityTAS
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP
GO:0007190activation of adenylate cyclase activityEXP
GO:0007202activation of phospholipase C activityTAS
GO:0007264small GTPase mediated signal transductionEXP
GO:0007265Ras protein signal transductionEXP
GO:0007275multicellular organismal developmentIEA
GO:0007399nervous system developmentIEA
GO:0030154cell differentiationIEA
GO:0048011nerve growth factor receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
Component
IDNameEvidence
GO:0005768endosomeEXP
GO:0005768endosomeTAS
GO:0005886plasma membraneEXP
GO:0005886plasma membraneTAS
GO:0005887integral to plasma membraneIEA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0004675transmembrane receptor protein serine/threonine kinase activityTAS
GO:0004714transmembrane receptor protein tyrosine kinase activityIEA
GO:0005030neurotrophin receptor activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0043121neurotrophin bindingTAS
GeneCards NTRK1
PDB 1HE7, 2IFG, 1WWW, 1WWA, 1SHC
UniProt P04629, A6NF12
MIM 191315
Ensembl ENSG00000198400
HGNC 8031
HPRD 01869

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