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NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001007792 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 3, mRNA. ORF Sequence $662.07
Peptide Services
Antibody Services
Protein Services
NM_001012331 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 1, mRNA. ORF Sequence $688.17
Peptide Services
Antibody Services
Protein Services
NM_002529 Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 2, mRNA. ORF Sequence $693.39
Peptide Services
Antibody Services
Protein Services


Gene Symbol NTRK1
Entrez Gene ID 4914
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms DKFZp781I14186, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q21-q22

Summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191315

Insensitivity to pain, congenital, with anhidrosis, 256800 (3);

mRNA Protein Product Sequence Price Select
NM_001007792, 56118209 NP_001007793, 56118210 high affinity nerve growth factor receptor isoform 3 Full Length $748.49
ORF Sequence $662.07
NM_001012331, 59889557 NP_001012331, 59889558 high affinity nerve growth factor receptor isoform 1 Full Length $767.63
ORF Sequence $688.17
NM_002529, 59889556 NP_002520, 4585712 high affinity nerve growth factor receptor isoform 2 Full Length $772.27
ORF Sequence $693.39
KEGG
hsa04210Apoptosis
hsa05202Transcriptional misregulation in cancer
hsa04722Neurotrophin signaling pathway
hsa05216Thyroid cancer
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa04144Endocytosis
Pathway Interaction Database
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
WikiPathways
WP2377Integrated Pancreatic Cancer Pathway
WP382MAPK signaling pathway
WP2256Integrated Pancreatic Cancer Pathway
Reactome
REACT_12049Signalling to STAT3
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12002ARMS-mediated activation
REACT_12033Signalling to RAS
REACT_12464PI3K/AKT activation
REACT_12079PLC-gamma1 signalling
REACT_12005Prolonged ERK activation events
REACT_11060TRKA activation by NGF
REACT_11046NGF-independant TRKA activation
REACT_12058Signalling to ERKs
REACT_12435Retrograde neurotrophin signalling
REACT_111102Signal Transduction
REACT_11061Signalling by NGF
REACT_12077Signalling to p38 via RIT and RIN
REACT_11064Activation of TRKA receptors
REACT_12076Frs2-mediated activation
Homo sapiens (human)NTRK1NP_002520.2
Pan troglodytes (chimpanzee)NTRK1XP_003308563.1
Macaca mulatta (Rhesus monkey)NTRK1XP_001114243.2
Canis lupus familiaris (dog)NTRK1XP_851619.3
Bos taurus (cattle)NTRK1XP_002686011.1
Mus musculus (house mouse)Ntrk1NP_001028296.1
Rattus norvegicus (Norway rat)Ntrk1NP_067600.1
Gallus gallus (chicken)NTRK1NP_990709.1
Danio rerio (zebrafish)ntrk1XP_697246.4
GeneCards NTRK1
PDB 2IFG, 1WWA, 1SHC, 4AOJ, 4F0I, 1HE7, 4GT5, 1WWW
UniProt P04629
MIM 191315
Ensembl ENSG00000198400
HGNC 8031
HPRD 01869

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
high affinity nerve growth factor receptor
Names
high affinity nerve growth factor receptor
gp140trk
Oncogene TRK
tyrosine kinase receptor A
tropomyosin-related kinase A
TRK1-transforming tyrosine kinase protein
NP_001007793.1
NP_001012331.1
NP_002520.2

Interactant

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