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P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21348 NM_002558 Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu49846 XM_006721529 PREDICTED: Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu21348C NM_002558 Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), mRNA. Customized vector In-stock 5-7 $149.00
OHu49846C XM_006721529 PREDICTED: Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol P2RX1
Entrez Gene ID 5023
Full Name purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms P2X1
General protein information
Preferred Names
P2X purinoceptor 1
Names
P2X purinoceptor 1
ATP receptor
P2X1 receptor
P2X receptor, subunit 1
purinergic receptor P2X1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.3

Summary The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013].
Disorder

MIM: 600845

Bleeding disorder due to P2RX1 defect (3)

mRNA Protein Product Sequence Price Select
NM_002558, 518832032 NP_002549, 4505545 P2X purinoceptor 1 ORF Sequence $269.00
XM_006721529, 578829910 XP_006721592, 578829911 P2X purinoceptor 1 isoform X2 ORF Sequence $400.00
KEGG
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04611Platelet activation
Reactome
REACT_604Hemostasis
REACT_162Elevation of cytosolic Ca2+ levels
REACT_23876Platelet homeostasis
REACT_23905Platelet calcium homeostasis
Homo sapiens (human)P2RX1NP_002549.1
Pan troglodytes (chimpanzee)P2RX1XP_511276.2
Macaca mulatta (Rhesus monkey)P2RX1XP_001092205.1
Canis lupus familiaris (dog)P2RX1XP_548344.1
Bos taurus (cattle)P2RX1NP_001192729.1
Mus musculus (house mouse)P2rx1NP_032797.3
Rattus norvegicus (Norway rat)P2rx1NP_037129.1
Gallus gallus (chicken)P2RX1NP_989850.1
Danio rerio (zebrafish)p2rx1NP_945333.1
Xenopus (Silurana) tropicalis (western clawed frog)p2rx1XP_002932325.2
Process
IDNameEvidence
GO:0002554serotonin secretion by plateletIEA
GO:0003056regulation of vascular smooth muscle contractionIEA
GO:0006810transportTAS
GO:0006811ion transportIDA
GO:0006812cation transportIBA
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIEA
GO:0007165signal transductionTAS
GO:0007320inseminationIEA
GO:0007596blood coagulationTAS
GO:0008217regulation of blood pressureIEA
GO:0019228neuronal action potentialIEA
GO:0030168platelet activationIEA
GO:0033198response to ATPIEA
GO:0035249synaptic transmission, glutamatergicIEA
GO:0035590purinergic nucleotide receptor signaling pathwayIDA
GO:0035590purinergic nucleotide receptor signaling pathwayIEA
GO:0042310vasoconstrictionIEA
GO:0043270positive regulation of ion transportIEA
GO:0046513ceramide biosynthetic processIEA
GO:0051260protein homooligomerizationIEA
GO:0051291protein heterooligomerizationIEA
GO:0051924regulation of calcium ion transportIEA
GO:0070588calcium ion transmembrane transportTAS
Component
IDNameEvidence
GO:0005639integral component of nuclear inner membraneIBA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0031240external side of cell outer membraneIEA
GO:0043005neuron projectionIEA
GO:0043234protein complexIEA
GO:0045121membrane raftIEA
GO:0045211postsynaptic membraneIEA
Function
IDNameEvidence
GO:0001614purinergic nucleotide receptor activityIDA
GO:0004931extracellular ATP-gated cation channel activityIBA
GO:0005261cation channel activityIDA
GO:0005262calcium channel activityTAS
GO:0005524ATP bindingIEA
GO:0008144drug bindingIEA
GO:0008270zinc ion bindingIEA
GeneCards P2RX1
UniProt P51575
Vega OTTHUMG00000177673
MIM 600845
Ensembl ENSG00000108405
HGNC 8533
HPRD 07526

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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