P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 [Homo sapiens (human)]

Gene Symbol	P2RX1
Entrez Gene ID	5023
Full Name	purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms	P2X1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17p13.3
Summary	The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq].
Disorder	MIM: 600845 Bleeding disorder due to P2RX1 defect (3)

KEGG

hsa04080	Neuroactive ligand-receptor interaction
hsa04020	Calcium signaling pathway

Reactome

REACT_23905	Platelet calcium homeostasis
REACT_23876	Platelet homeostasis
REACT_798	Platelet Activation
REACT_162	Elevation of cytosolic Ca2+ levels
REACT_20	Formation of Platelet plug
REACT_604	Hemostasis

Homo sapiens (human)	P2RX1	NP_002549.1
Pan troglodytes (chimpanzee)	P2RX1	XP_511276.2
Canis lupus familiaris (dog)	P2RX1	XP_548344.1
Bos taurus (cattle)	P2RX1	XP_592814.2
Mus musculus (house mouse)	P2rx1	NP_032797.2
Rattus norvegicus (Norway rat)	P2rx1	NP_037129.1
Gallus gallus (chicken)	P2RX1	NP_989850.1
Danio rerio (zebrafish)	p2rx1	NP_945333.1

Process

ID	Name	Evidence
GO:0002554	serotonin secretion by platelet	IEA
GO:0003056	regulation of vascular smooth muscle contraction	IEA
GO:0006810	transport	TAS
GO:0006811	ion transport	IDA
GO:0006812	cation transport	ISS
GO:0006919	activation of caspase activity	IEA
GO:0007165	signal transduction	TAS
GO:0007320	insemination	IEA
GO:0007596	blood coagulation	TAS
GO:0008217	regulation of blood pressure	IEA
GO:0016265	death	IEA
GO:0019228	regulation of action potential in neuron	IEA
GO:0030168	platelet activation	TAS
GO:0033198	response to ATP	IEA
GO:0035249	synaptic transmission, glutamatergic	IEA
GO:0035590	purinergic nucleotide receptor signaling pathway	IDA
GO:0043270	positive regulation of ion transport	IEA
GO:0046513	ceramide biosynthetic process	IEA
GO:0050896	response to stimulus	IEA
GO:0051260	protein homooligomerization	IEA
GO:0051291	protein heterooligomerization	IEA
GO:0051924	regulation of calcium ion transport	IEA
GO:0070588	calcium ion transmembrane transport	TAS

Component

ID	Name	Evidence
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	TAS
GO:0005887	integral to plasma membrane	TAS
GO:0019717	synaptosome	IEA
GO:0031240	external side of cell outer membrane	IEA
GO:0043234	protein complex	IEA
GO:0045121	membrane raft	IEA
GO:0045211	postsynaptic membrane	IEA

Function

ID	Name	Evidence
GO:0001614	purinergic nucleotide receptor activity	IDA
GO:0004872	receptor activity	IEA
GO:0004931	extracellular ATP-gated cation channel activity	ISS
GO:0005261	cation channel activity	IDA
GO:0005262	calcium channel activity	TAS
GO:0005524	ATP binding	IEA
GO:0008144	drug binding	IEA
GO:0008270	zinc ion binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_002558	Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), mRNA.	Full Length	$843.90
NM_002558		ORF Sequence	$348.00