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P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002558 Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol P2RX1
Entrez Gene ID 5023
Full Name purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms P2X1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.3

Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600845

Bleeding disorder due to P2RX1 defect (3)

mRNA Protein Product Sequence Price Select
NM_002558, 27894283 NP_002549, 4505545 P2X purinoceptor 1 ORF Sequence $269.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Reactome
REACT_23876Platelet homeostasis
REACT_604Hemostasis
REACT_23905Platelet calcium homeostasis
REACT_162Elevation of cytosolic Ca2+ levels
Homo sapiens (human)P2RX1NP_002549.1
Pan troglodytes (chimpanzee)P2RX1XP_511276.2
Macaca mulatta (Rhesus monkey)P2RX1XP_001092205.1
Canis lupus familiaris (dog)P2RX1XP_548344.1
Bos taurus (cattle)P2RX1NP_001192729.1
Mus musculus (house mouse)P2rx1NP_032797.3
Rattus norvegicus (Norway rat)P2rx1NP_037129.1
Gallus gallus (chicken)P2RX1NP_989850.1
Danio rerio (zebrafish)p2rx1NP_945333.1
GeneCards P2RX1
UniProt P51575
MIM 600845
Ensembl ENSG00000108405
HGNC 8533
HPRD 07526

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
P2X purinoceptor 1
Names
P2X purinoceptor 1
ATP receptor
P2X1 receptor
P2X receptor, subunit 1
purinergic receptor P2X1

Interactant



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