PRDX1 peroxiredoxin 1 [Homo sapiens (human)]
| Gene Symbol | PRDX1 |
| Entrez Gene ID | 5052 |
| Full Name | peroxiredoxin 1 |
| Synonyms | MSP23, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p34.1 |
| Summary | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]. |
| Disorder | MIM: 176763 |
| mRNA | NM_181697, 320461707 |
| Protein | NP_859048, 32455266 |
| Product | peroxiredoxin-1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_181696, 320461708 |
| Protein | NP_859047, 32455264 |
| Product | peroxiredoxin-1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_002574, 320461709 |
| Protein | NP_002565, 4505591 |
| Product | peroxiredoxin-1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001202431, 320461710 |
| Protein | NP_001189360, 320461711 |
| Product | peroxiredoxin-1 |
| RefSeq Status | REVIEWED |
| hsa04146 | Peroxisome |
WikiPathways
| WP15 | Selenium Pathway |
Pathway Interaction Database
| ar_pathway | Coregulation of Androgen receptor activity |
| Homo sapiens (human) | PRDX1 | NP_002565.1 |
| Pan troglodytes (chimpanzee) | PRDX1 | XP_001156454.1 |
| Canis lupus familiaris (dog) | PRDX1 | XP_532599.2 |
| Bos taurus (cattle) | PRDX1 | NP_776856.1 |
| Mus musculus (house mouse) | Prdx1 | NP_035164.1 |
| Rattus norvegicus (Norway rat) | Prdx1 | NP_476455.1 |
| Gallus gallus (chicken) | PRDX1 | XP_001233893.1 |
| Danio rerio (zebrafish) | zgc:110343 | NP_001013489.1 |
| ID | Name | Evidence |
| GO:0001501 | skeletal system development | TAS |
| GO:0008283 | cell proliferation | TAS |
| GO:0042744 | hydrogen peroxide catabolic process | IDA |
| GO:0045454 | cell redox homeostasis | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005739 | mitochondrion | IDA |
| GO:0042470 | melanosome | IEA |
Function
| ID | Name | Evidence |
| GO:0004601 | peroxidase activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008379 | thioredoxin peroxidase activity | IDA |
| GO:0016491 | oxidoreductase activity | IEA |
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