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PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004562 Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_013987 Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_013988 Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol PARK2
Entrez Gene ID 5071
Full Name parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Synonyms AR-JP, LPRS2, PDJ, PRKN
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q25.2-q27

Summary The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602544

Parkinson disease, juvenile, type 2, 600116 (3); Adenocarcinoma of

mRNA Protein Product Sequence Price Select
NM_004562, 169790968 NP_004553, 169790969 E3 ubiquitin-protein ligase parkin isoform 1 ORF Sequence $550.00
NM_013987, 169790970 NP_054642, 169790971 E3 ubiquitin-protein ligase parkin isoform 2 ORF Sequence $550.00
NM_013988, 169790972 NP_054643, 169790973 E3 ubiquitin-protein ligase parkin isoform 3 ORF Sequence $400.00
KEGG
hsa05012Parkinson's disease
hsa04120Ubiquitin mediated proteolysis
hsa04141Protein processing in endoplasmic reticulum
WikiPathways
WP2359Parkin-Ubiquitin Proteasomal System pathway
WP2371Parkinsons Disease Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Reactome
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
Homo sapiens (human)PARK2NP_004553.2
Pan troglodytes (chimpanzee)PARK2XP_001153913.1
Macaca mulatta (Rhesus monkey)LOC710899XP_001099588.2
Canis lupus familiaris (dog)PARK2XP_855152.2
Bos taurus (cattle)PARK2NP_001185994.1
Mus musculus (house mouse)Park2NP_057903.1
Rattus norvegicus (Norway rat)Park2NP_064478.1
Gallus gallus (chicken)PARK2XP_419615.2
Danio rerio (zebrafish)park2NP_001017635.1
Drosophila melanogaster (fruit fly)parkNP_730601.1
Caenorhabditis eleganspdr-1NP_499846.2
GeneCards PARK2
PDB 2JMO, 1IYF
UniProt Q5VVX4, O60260
MIM 602544
Ensembl ENSG00000185345
HGNC 8607
HPRD 03967

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
E3 ubiquitin-protein ligase parkin
Names
E3 ubiquitin-protein ligase parkin
parkinson juvenile disease protein 2
Parkinson disease (autosomal recessive, juvenile) 2, parkin

Interactant



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