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PARK2 parkin RBR E3 ubiquitin protein ligase [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004562 Homo sapiens parkin RBR E3 ubiquitin protein ligase (PARK2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_013987 Homo sapiens parkin RBR E3 ubiquitin protein ligase (PARK2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_013988 Homo sapiens parkin RBR E3 ubiquitin protein ligase (PARK2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol PARK2
Entrez Gene ID 5071
Full Name parkin RBR E3 ubiquitin protein ligase
Synonyms AR-JP, LPRS2, PDJ, PRKN
General protein information
Preferred Names
E3 ubiquitin-protein ligase parkin
E3 ubiquitin-protein ligase parkin
parkinson juvenile disease protein 2
Parkinson disease (autosomal recessive, juvenile) 2, parkin
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008].

MIM: 602544

Parkinson disease, juvenile, type 2, 600116 (3); Adenocarcinoma of

mRNA Protein Product Sequence Price Select
NM_004562, 169790968 NP_004553, 169790969 E3 ubiquitin-protein ligase parkin isoform 1 ORF Sequence $550.00
NM_013987, 169790970 NP_054642, 169790971 E3 ubiquitin-protein ligase parkin isoform 2 ORF Sequence $550.00
NM_013988, 169790972 NP_054643, 169790973 E3 ubiquitin-protein ligase parkin isoform 3 ORF Sequence $400.00
hsa04120Ubiquitin mediated proteolysis
hsa05012Parkinson's disease
hsa04141Protein processing in endoplasmic reticulum
WP2359Parkin-Ubiquitin Proteasomal System pathway
WP2371Parkinsons Disease Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
Homo sapiens (human)PARK2NP_004553.2
Pan troglodytes (chimpanzee)PARK2XP_001153913.1
Macaca mulatta (Rhesus monkey)LOC710899XP_001099588.2
Canis lupus familiaris (dog)PARK2XP_855152.2
Bos taurus (cattle)PARK2NP_001185994.1
Mus musculus (house mouse)Park2NP_057903.1
Rattus norvegicus (Norway rat)Park2NP_064478.1
Gallus gallus (chicken)PARK2XP_004935613.1
Danio rerio (zebrafish)park2NP_001017635.1
Drosophila melanogaster (fruit fly)parkNP_730601.1
Caenorhabditis eleganspdr-1NP_499846.2
GO:0000209protein polyubiquitinationIDA
GO:0000422mitochondrion degradationIMP
GO:0001933negative regulation of protein phosphorylationIDA
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0006511ubiquitin-dependent protein catabolic processIDA
GO:0006513protein monoubiquitinationIDA
GO:0007417central nervous system developmentTAS
GO:0008219cell deathIDA
GO:0010506regulation of autophagyIDA
GO:0016567protein ubiquitinationIMP
GO:0032232negative regulation of actin filament bundle assemblyIDA
GO:0033132negative regulation of glucokinase activityIDA
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processIDA
GO:0043524negative regulation of neuron apoptotic processIDA
GO:0044257cellular protein catabolic processIMP
GO:0046676negative regulation of insulin secretionIDA
GO:0051865protein autoubiquitinationIDA
GO:0060548negative regulation of cell deathIDA
GO:0070534protein K63-linked ubiquitinationIDA
GO:0070842aggresome assemblyIMP
GO:0070936protein K48-linked ubiquitinationIDA
GO:0070997neuron deathIDA
GO:0090201negative regulation of release of cytochrome c from mitochondriaIDA
GO:1901215negative regulation of neuron deathIGI
GO:2000377regulation of reactive oxygen species metabolic processIMP
GO:0000151ubiquitin ligase complexIDA
GO:0005783endoplasmic reticulumIEA
GO:0005794Golgi apparatusIDA
GO:0048471perinuclear region of cytoplasmIDA
GO:0004842ubiquitin-protein transferase activityIDA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0016874ligase activityIEA
GO:0019900kinase bindingIPI
GO:0019901protein kinase bindingIPI
GO:0030165PDZ domain bindingIPI
GO:0031625ubiquitin protein ligase bindingIPI
GO:0042802identical protein bindingIPI
GO:0043130ubiquitin bindingIDA
GO:0051087chaperone bindingIPI
GO:0061630ubiquitin protein ligase activityIDA
GO:1990381ubiquitin-specific protease bindingIPI
GeneCards PARK2
UniProt X5DR79, O60260
Vega OTTHUMG00000015970
MIM 602544
Ensembl ENSG00000185345
HGNC 8607
HPRD 03967

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PARK2 gene?

The PARK2 gene, one of the largest human genes, provides instructions for making a protein called parkin. Parkin plays a role in the cell machinery that breaks down (degrades) unneeded proteins by tagging damaged and excess proteins with molecules called ubiquitin. Ubiquitin serves as a signal to move unneeded proteins into specialized cell structures known as proteasomes, where the proteins are degraded. The ubiquitin-proteasome system acts as the cell's quality control system by disposing of damaged, misshapen, and excess proteins. This system also regulates the availability of proteins that are involved in several critical cell activities, such as the timing of cell division and growth. Because of its activity in the ubiquitin-proteasome system, parkin belongs to a group of proteins called E3 ubiquitin ligases.

Parkin appears to be involved in the maintenance of mitochondria, the energy-producing centers in cells. However, little is known about its role in mitochondrial function. Research suggests that parkin may help trigger the destruction of mitochondria that are not working properly.

Studies of the structure and activity of parkin have led researchers to propose several additional activities for this protein. Parkin may act as a tumor suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. Parkin may also regulate the supply and release of sacs called synaptic vesicles from nerve cells. Synaptic vesicles contain chemical messengers that transmit signals from one nerve cell to another.


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