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Sequence in raw or FASTA format:

Database:

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FOXP3 forkhead box P3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26074 NM_014009 Homo sapiens forkhead box P3 (FOXP3), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26407 NM_001114377 Homo sapiens forkhead box P3 (FOXP3), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu53997 XM_006724533 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu53998 XM_005272610 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu53999 XM_005272611 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu26074C NM_014009 Homo sapiens forkhead box P3 (FOXP3), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu26407C NM_001114377 Homo sapiens forkhead box P3 (FOXP3), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu53997C XM_006724533 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00
OHu53998C XM_005272610 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu53999C XM_005272611 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol FOXP3
Entrez Gene ID 50943
Full Name forkhead box P3
Synonyms AIID, DIETER, IPEX, PIDX, XPID
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.23

Summary The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 300292

Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked,

mRNA Protein Product Sequence Price Select
NM_001114377, 167466189 NP_001107849, 167466190 forkhead box protein P3 isoform b ORF Sequence $400.00
NM_014009, 167466188 NP_054728, 31982943 forkhead box protein P3 isoform a ORF Sequence $360.00
XM_005272610, 578838028 XP_005272667, 578838029 forkhead box protein P3 isoform X1 ORF Sequence $550.00
XM_005272611, 578838030 XP_005272668, 578838031 forkhead box protein P3 isoform X2 ORF Sequence $550.00
XM_006724533, 578838026 XP_006724596, 578838027 forkhead box protein P3 isoform X3 ORF Sequence $550.00
KEGG
hsa05321Inflammatory bowel disease (IBD)
Pathway Interaction Database
il2_stat5pathwayIL2 signaling events mediated by STAT5
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
Homo sapiens (human)FOXP3NP_054728.2
Macaca mulatta (Rhesus monkey)FOXP3NP_001028090.1
Canis lupus familiaris (dog)FOXP3NP_001161933.1
Bos taurus (cattle)FOXP3NP_001039398.1
Mus musculus (house mouse)Foxp3NP_473380.1
Rattus norvegicus (Norway rat)Foxp3NP_001101720.1
Xenopus (Silurana) tropicalis (western clawed frog)foxp3XP_002941017.2
Process
IDNameEvidence
GO:0001782B cell homeostasisIEA
GO:0001816cytokine productionIEA
GO:0002262myeloid cell homeostasisIEA
GO:0002361CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIEA
GO:0002456T cell mediated immunityIEA
GO:0002513tolerance induction to self antigenIEA
GO:0002669positive regulation of T cell anergyIEA
GO:0002677negative regulation of chronic inflammatory responseIEA
GO:0002725negative regulation of T cell cytokine productionIDA
GO:0002851positive regulation of peripheral T cell tolerance inductionIEA
GO:0006338chromatin remodelingNAS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0009615response to virusIEP
GO:0031064negative regulation of histone deacetylationIGI
GO:0032088negative regulation of NF-kappaB transcription factor activityIDA
GO:0032689negative regulation of interferon-gamma productionIDA
GO:0032693negative regulation of interleukin-10 productionIDA
GO:0032703negative regulation of interleukin-2 productionIDA
GO:0032713negative regulation of interleukin-4 productionIDA
GO:0032714negative regulation of interleukin-5 productionIEA
GO:0032715negative regulation of interleukin-6 productionIEA
GO:0032720negative regulation of tumor necrosis factor productionIEA
GO:0032753positive regulation of interleukin-4 productionIEA
GO:0032792negative regulation of CREB transcription factor activityIDA
GO:0032831positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIEA
GO:0032914positive regulation of transforming growth factor beta1 productionIEA
GO:0033092positive regulation of immature T cell proliferation in thymusIEA
GO:0035066positive regulation of histone acetylationIMP
GO:0035067negative regulation of histone acetylationIEA
GO:0042036negative regulation of cytokine biosynthetic processIDA
GO:0042110T cell activationIDA
GO:0042130negative regulation of T cell proliferationIDA
GO:0043029T cell homeostasisNAS
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0045077negative regulation of interferon-gamma biosynthetic processIEA
GO:0045085negative regulation of interleukin-2 biosynthetic processIMP
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0046007negative regulation of activated T cell proliferationNAS
GO:0048294negative regulation of isotype switching to IgE isotypesIEA
GO:0048302regulation of isotype switching to IgG isotypesIEA
GO:0050710negative regulation of cytokine secretionIDA
GO:0050777negative regulation of immune responseIDA
GO:0050852T cell receptor signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005737cytoplasmIEA
GO:0005737cytoplasmNAS
GO:0043234protein complexNAS
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA
GO:0003714transcription corepressor activityIEA
GO:0005515protein bindingIPI
GO:0035035histone acetyltransferase bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0042826histone deacetylase bindingIPI
GO:0043565sequence-specific DNA bindingIDA
GO:0046872metal ion bindingIEA
GO:0051059NF-kappaB bindingNAS
GO:0051525NFAT protein bindingIPI
GeneCards FOXP3
UniProt Q9BZS1
Vega OTTHUMG00000024135
MIM 300292
Ensembl ENSG00000049768
HGNC 6106
HPRD 02242

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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