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FOXP3 forkhead box P3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001114377 Homo sapiens forkhead box P3 (FOXP3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_014009 Homo sapiens forkhead box P3 (FOXP3), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_005272610 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005272611 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006724533 PREDICTED: Homo sapiens forkhead box P3 (FOXP3), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

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Gene Symbol FOXP3
Entrez Gene ID 50943
Full Name forkhead box P3
Synonyms AIID, DIETER, IPEX, PIDX, XPID
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.23

Summary The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 300292

Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked,

mRNA Protein Product Sequence Price Select
NM_001114377, 167466189 NP_001107849, 167466190 forkhead box protein P3 isoform b ORF Sequence $400.00
NM_014009, 167466188 NP_054728, 31982943 forkhead box protein P3 isoform a ORF Sequence $360.00
XM_005272610, 578838028 XP_005272667, 578838029 forkhead box protein P3 isoform X1 ORF Sequence $550.00
XM_005272611, 578838030 XP_005272668, 578838031 forkhead box protein P3 isoform X2 ORF Sequence $550.00
XM_006724533, 578838026 XP_006724596, 578838027 forkhead box protein P3 isoform X3 ORF Sequence $550.00
KEGG
hsa05321Inflammatory bowel disease (IBD)
Pathway Interaction Database
il2_stat5pathwayIL2 signaling events mediated by STAT5
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
Homo sapiens (human)FOXP3NP_054728.2
Macaca mulatta (Rhesus monkey)FOXP3NP_001028090.1
Canis lupus familiaris (dog)FOXP3NP_001161933.1
Bos taurus (cattle)FOXP3NP_001039398.1
Mus musculus (house mouse)Foxp3NP_473380.1
Rattus norvegicus (Norway rat)Foxp3NP_001101720.1
Xenopus (Silurana) tropicalis (western clawed frog)foxp3XP_002941017.2
Process
IDNameEvidence
GO:0001782B cell homeostasisIEA
GO:0001816cytokine productionIEA
GO:0002262myeloid cell homeostasisIEA
GO:0002361CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIEA
GO:0002456T cell mediated immunityIEA
GO:0002513tolerance induction to self antigenIEA
GO:0002669positive regulation of T cell anergyIEA
GO:0002677negative regulation of chronic inflammatory responseIEA
GO:0002725negative regulation of T cell cytokine productionIDA
GO:0002851positive regulation of peripheral T cell tolerance inductionIEA
GO:0006338chromatin remodelingNAS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0009615response to virusIEP
GO:0031064negative regulation of histone deacetylationIGI
GO:0032088negative regulation of NF-kappaB transcription factor activityIDA
GO:0032689negative regulation of interferon-gamma productionIDA
GO:0032693negative regulation of interleukin-10 productionIDA
GO:0032703negative regulation of interleukin-2 productionIDA
GO:0032713negative regulation of interleukin-4 productionIDA
GO:0032714negative regulation of interleukin-5 productionIEA
GO:0032715negative regulation of interleukin-6 productionIEA
GO:0032720negative regulation of tumor necrosis factor productionIEA
GO:0032753positive regulation of interleukin-4 productionIEA
GO:0032792negative regulation of CREB transcription factor activityIDA
GO:0032831positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiationIEA
GO:0032914positive regulation of transforming growth factor beta1 productionIEA
GO:0033092positive regulation of immature T cell proliferation in thymusIEA
GO:0035066positive regulation of histone acetylationIMP
GO:0035067negative regulation of histone acetylationIEA
GO:0042036negative regulation of cytokine biosynthetic processIDA
GO:0042110T cell activationIDA
GO:0042130negative regulation of T cell proliferationIDA
GO:0043029T cell homeostasisNAS
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0045077negative regulation of interferon-gamma biosynthetic processIEA
GO:0045085negative regulation of interleukin-2 biosynthetic processIMP
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0046007negative regulation of activated T cell proliferationNAS
GO:0048294negative regulation of isotype switching to IgE isotypesIEA
GO:0048302regulation of isotype switching to IgG isotypesIEA
GO:0050710negative regulation of cytokine secretionIDA
GO:0050777negative regulation of immune responseIDA
GO:0050852T cell receptor signaling pathwayIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005737cytoplasmIEA
GO:0005737cytoplasmNAS
GO:0043234protein complexNAS
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA
GO:0003714transcription corepressor activityIEA
GO:0005515protein bindingIPI
GO:0035035histone acetyltransferase bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0042826histone deacetylase bindingIPI
GO:0043565sequence-specific DNA bindingIDA
GO:0046872metal ion bindingIEA
GO:0051059NF-kappaB bindingNAS
GO:0051525NFAT protein bindingIPI
GeneCards FOXP3
UniProt Q9BZS1
Vega OTTHUMG00000024135
MIM 300292
Ensembl ENSG00000049768
HGNC 6106
HPRD 02242

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FOXP3 gene?

The FOXP3 gene provides instructions for producing the forkhead box P3 (FOXP3) protein. The FOXP3 protein attaches (binds) to specific regions of DNA and helps control the activity of genes that are involved in regulating the immune system. On the basis of this role, the FOXP3 protein is called a transcription factor. This protein is essential for the production and normal function of certain immune cells called regulatory T cells, which play an important role in preventing autoimmunity. Autoimmunity occurs when the body attacks its own tissues and organs by mistake. The FOXP3 protein is found primarily in an immune system gland called the thymus, where regulatory T cells are produced.

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