GLRX5 glutaredoxin 5 [Homo sapiens (human)]
| Gene Symbol | GLRX5 |
| Entrez Gene ID | 51218 |
| Full Name | glutaredoxin 5 |
| Synonyms | C14orf87, FLB4739, GRX5, MGC14129, PR01238, PRO1238 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
14 14q32.13 |
| Summary | This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 609588 Anemia, sideroblastic, pyridoxine-refractory, autosomal recessive, |
| mRNA | NM_016417, 42516575 |
| Protein | NP_057501, 42516576 |
| Product | glutaredoxin-related protein 5, mitochondrial precursor |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | GLRX5 | NP_057501.2 |
| Pan troglodytes (chimpanzee) | GLRX5 | XP_001154482.1 |
| Bos taurus (cattle) | GLRX5 | NP_001093773.1 |
| Mus musculus (house mouse) | Glrx5 | NP_082695.1 |
| Rattus norvegicus (Norway rat) | Glrx5 | XP_343104.3 |
| Gallus gallus (chicken) | GLRX5 | NP_001008472.1 |
| Danio rerio (zebrafish) | glrx5 | NP_998186.1 |
| Drosophila melanogaster (fruit fly) | CG14407 | NP_572974.1 |
| Caenorhabditis elegans | glrx-5 | NP_499610.1 |
| Arabidopsis thaliana (thale cress) | CXIP1 | NP_191050.1 |
| ID | Name | Evidence |
| GO:0030097 | hemopoiesis | ISS |
| GO:0045454 | cell redox homeostasis | IEA |
Component
| ID | Name | Evidence |
| GO:0005739 | mitochondrion | ISS |
Function
| ID | Name | Evidence |
| GO:0009055 | electron carrier activity | IEA |
| GO:0015035 | protein disulfide oxidoreductase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IEA |
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