PADI3 peptidyl arginine deiminase, type III [Homo sapiens (human)]
| Gene Symbol | PADI3 |
| Entrez Gene ID | 51702 |
| Full Name | peptidyl arginine deiminase, type III |
| Synonyms | MGC126307, MGC126308, PAD3, PDI3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36.13 |
| Summary | This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq]. |
| Disorder | MIM: 606755 |
| mRNA | NM_016233, 122939160 |
| Protein | NP_057317, 122939161 |
| Product | protein-arginine deiminase type-3 |
| RefSeq Status | REVIEWED |
| META_PWY-4921 | protein citrullination |
| Homo sapiens (human) | PADI3 | NP_057317.2 |
| Pan troglodytes (chimpanzee) | PADI3 | XP_524563.1 |
| Canis lupus familiaris (dog) | PADI3 | XP_535391.2 |
| Mus musculus (house mouse) | Padi3 | NP_035190.1 |
| Rattus norvegicus (Norway rat) | Padi3 | NP_058926.1 |
| Gallus gallus (chicken) | PADI3 | NP_990374.1 |
| ID | Name | Evidence |
| GO:0006464 | protein modification process | IEA |
| GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine | IEA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
Function
| ID | Name | Evidence |
| GO:0004668 | protein-arginine deiminase activity | IEA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0016787 | hydrolase activity | IEA |
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