Search Tips

  • THAT   AND
  • THAT   AND


ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_001693 Homo sapiens ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (ATP6V1B2), mRNA. Full Length $1068.90
ORF Sequence $445.44


Gene Symbol ATP6V1B2
Entrez Gene ID 526
Full Name ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Synonyms ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p21.3
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq].
Disorder

MIM: 606939
mRNA NM_001693, 87159809
Protein NP_001684, 19913428
Product V-type proton ATPase subunit B, brain isoform
RefSeq Status REVIEWED
KEGG
hsa04966Collecting duct acid secretion
hsa04145Phagosome
hsa05323Rheumatoid arthritis
hsa01100Metabolic pathways
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa00190Oxidative phosphorylation
hsa05110Vibrio cholerae infection
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25060Iron uptake and transport
REACT_25283Transferrin endocytosis and recycling
REACT_1109Insulin receptor recycling
REACT_498Signaling by Insulin receptor
Homo sapiens (human)ATP6V1B2NP_001684.2
Pan troglodytes (chimpanzee)ATP6V1B2XP_519638.2
Canis lupus familiaris (dog)ATP6V1B2XP_543263.2
Bos taurus (cattle)ATP6V1B2NP_788844.2
Mus musculus (house mouse)Atp6v1b2NP_031535.2
Rattus norvegicus (Norway rat)Atp6v1b2NP_476561.1
Gallus gallus (chicken)ATP6V1B2XP_424534.2
Danio rerio (zebrafish)LOC100332756XP_002663572.1
Danio rerio (zebrafish)atp6v1b2NP_878299.1
Drosophila melanogaster (fruit fly)Vha55NP_001163597.1
Caenorhabditis elegansvha-12NP_508711.1
Caenorhabditis eleganstag-300NP_491518.1
Arabidopsis thaliana (thale cress)AT1G76030NP_177729.1
Arabidopsis thaliana (thale cress)AT1G20260NP_173451.5
Process
IDNameEvidence
GO:0006811ion transportIEA
GO:0006879cellular iron ion homeostasisTAS
GO:0008286insulin receptor signaling pathwayTAS
GO:0015991ATP hydrolysis coupled proton transportIEA
GO:0015992proton transportTAS
GO:0033572transferrin transportEXP
GO:0046034ATP metabolic processIEA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005794Golgi apparatusIDA
GO:0005829cytosolEXP
GO:0005829cytosolISS
GO:0005829cytosolTAS
GO:0005886plasma membraneISS
GO:0012505endomembrane systemIEA
GO:0016021integral to membraneIEA
GO:0033180proton-transporting V-type ATPase, V1 domainIEA
GO:0042470melanosomeIEA
GO:0043231intracellular membrane-bounded organelleIDA
Function
IDNameEvidence
GO:0005524ATP bindingIEA
GO:0015078hydrogen ion transmembrane transporter activityTAS
GO:0016787hydrolase activityIEA
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesIEA
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanismIEA
GO:0046961proton-transporting ATPase activity, rotational mechanismIEA
GeneCards ATP6V1B2
UniProt P21281
MIM 606939
Ensembl ENSG00000147416
HGNC 854
HPRD 06088

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878