PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide [Homo sapiens (human)]

Gene Symbol	PIK3C2B
Entrez Gene ID	5287
Full Name	phosphoinositide-3-kinase, class 2, beta polypeptide
Synonyms	C2-PI3K, DKFZp686G16234
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:1 Map Location:1q32
Summary	The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq].
Disorder	MIM: 602838

mRNA	NM_002646, 194097346
Protein	NP_002637, 194097347
Product	phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
RefSeq Status	REVIEWED

KEGG

hsa00562	Inositol phosphate metabolism
hsa01100	Metabolic pathways
hsa04070	Phosphatidylinositol signaling system

WikiPathways

WP26	Signal Transduction of S1P Receptor
WP51	Regulation of Actin Cytoskeleton
WP437	EGFR1 Signaling Pathway

Pathway Interaction Database

kitpathway

Signaling events mediated by Stem cell factor receptor (c-Kit)

BIOCYC

META_PWY-6352	3-phosphoinositide biosynthesis
META_PWY-6371	superpathway of inositol phosphate compounds

Homo sapiens (human)	PIK3C2B	NP_002637.3
Pan troglodytes (chimpanzee)	PIK3C2B	XP_514126.2
Canis lupus familiaris (dog)	PIK3C2B	XP_536097.2
Bos taurus (cattle)	PIK3C2B	XP_001789145.1
Mus musculus (house mouse)	Pik3c2b	XP_001479708.1
Rattus norvegicus (Norway rat)	Pik3c2b	XP_213879.3
Gallus gallus (chicken)	PIK3C2B	XP_417956.2

Process

ID	Name	Evidence
GO:0007154	cell communication	IEA
GO:0008150	biological_process	ND
GO:0043491	protein kinase B signaling cascade	IEA
GO:0046854	phosphatidylinositol phosphorylation	IEA
GO:0048015	phosphatidylinositol-mediated signaling	IEA

Component

ID	Name	Evidence
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IEA
GO:0005783	endoplasmic reticulum	IEA
GO:0005792	microsome	NAS
GO:0005829	cytosol	NAS
GO:0005886	plasma membrane	NAS
GO:0005942	phosphatidylinositol 3-kinase complex	IEA
GO:0030139	endocytic vesicle	IEA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0001727	lipid kinase activity	IEA
GO:0004428	inositol or phosphatidylinositol kinase activity	IEA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0016303	1-phosphatidylinositol-3-kinase activity	IEA
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA
GO:0035005	phosphatidylinositol-4-phosphate 3-kinase activity	NAS
GO:0035091	phosphatidylinositol binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_002646	Homo sapiens phosphoinositide-3-kinase, class 2, beta polypeptide (PIK3C2B), mRNA.	Full Length	$3422.70
NM_002646		ORF Sequence	$1716.75