PLCB2 phospholipase C, beta 2 [Homo sapiens (human)]
| Gene Symbol | PLCB2 |
| Entrez Gene ID | 5330 |
| Full Name | phospholipase C, beta 2 |
| Synonyms | FLJ38135 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
15 15q15 |
| Summary | |
| Disorder | MIM: 604114 Platelet PLC beta-2 deficiency (1) |
| mRNA | NM_004573, 95147332 |
| Protein | NP_004564, 95147333 |
| Product | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 |
| RefSeq Status | VALIDATED |
| hsa04720 | Long-term potentiation |
| hsa04971 | Gastric acid secretion |
| hsa04916 | Melanogenesis |
| hsa04540 | Gap junction |
| hsa05143 | African trypanosomiasis |
| hsa04310 | Wnt signaling pathway |
| hsa00562 | Inositol phosphate metabolism |
| hsa04973 | Carbohydrate digestion and absorption |
| hsa01100 | Metabolic pathways |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05146 | Amoebiasis |
| hsa04730 | Long-term depression |
| hsa04972 | Pancreatic secretion |
| hsa04070 | Phosphatidylinositol signaling system |
| hsa04020 | Calcium signaling pathway |
| hsa04970 | Salivary secretion |
| hsa04912 | GnRH signaling pathway |
| hsa05016 | Huntington's disease |
| hsa04062 | Chemokine signaling pathway |
| hsa05010 | Alzheimer's disease |
| hsa04742 | Taste transduction |
| hsa04270 | Vascular smooth muscle contraction |
Pathway Interaction Database
| s1p_s1p1_pathway | S1P1 pathway |
| er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| endothelinpathway | Endothelins |
| txa2pathway | Thromboxane A2 receptor signaling |
| alphasynuclein_pathway | Alpha-synuclein signaling |
| cxcr4_pathway | CXCR4-mediated signaling events |
| rac1_pathway | RAC1 signaling pathway |
WikiPathways
| WP26 | Signal Transduction of S1P Receptor |
| WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
BIOCYC
| META_PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| META_PWY-6371 | superpathway of inositol phosphate compounds |
| META_PWY-6367 | D-myo-inositol-5-phosphate metabolism |
Reactome
| REACT_21254 | Presynaptic function of Kainate receptors |
| REACT_18325 | Regulation of Insulin Secretion |
| REACT_15295 | Opioid Signalling |
| REACT_19388 | G-protein beta:gamma signalling |
| REACT_15526 | G-protein mediated events |
| REACT_21312 | Activation of Kainate Receptors upon glutamate binding |
| REACT_19375 | Regulation of Insulin Secretion by Free Fatty Acids |
| REACT_18283 | G alpha (q) signalling events |
| REACT_15426 | PLC beta mediated events |
| REACT_13477 | Transmission across Chemical Synapses |
| REACT_1505 | Integration of energy metabolism |
| REACT_19145 | G beta:gamma signalling through PLC beta |
| REACT_19184 | GPCR downstream signaling |
| REACT_13685 | Synaptic Transmission |
| REACT_15370 | Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| REACT_18405 | Regulation of Insulin Secretion by Acetylcholine |
| REACT_14797 | Signaling by GPCR |
| REACT_15380 | Diabetes pathways |
| REACT_19193 | Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1) |
| Homo sapiens (human) | PLCB2 | NP_004564.2 |
| Pan troglodytes (chimpanzee) | PLCB2 | XP_001141721.1 |
| Canis lupus familiaris (dog) | PLCB2 | XP_544615.2 |
| Mus musculus (house mouse) | Plcb2 | NP_808236.2 |
| Rattus norvegicus (Norway rat) | Plcb2 | NP_445930.1 |
| Gallus gallus (chicken) | PLCB2 | XP_420945.2 |
| ID | Name | Evidence |
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IEA |
| GO:0006644 | phospholipid metabolic process | TAS |
| GO:0007202 | activation of phospholipase C activity | TAS |
| GO:0007268 | synaptic transmission | TAS |
| GO:0016042 | lipid catabolic process | IEA |
| GO:0035556 | intracellular signal transduction | IEA |
Component
| ID | Name | Evidence |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005886 | plasma membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004435 | phosphatidylinositol phospholipase C activity | IEA |
| GO:0004629 | phospholipase C activity | TAS |
| GO:0004871 | signal transducer activity | IEA |
| GO:0005509 | calcium ion binding | IEA |
| GO:0005543 | phospholipid binding | IEA |
| GO:0016787 | hydrolase activity | IEA |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |