SHC3 SHC (Src homology 2 domain containing) transforming protein 3 [Homo sapiens (human)]
| Gene Symbol | SHC3 |
| Entrez Gene ID | 53358 |
| Full Name | SHC (Src homology 2 domain containing) transforming protein 3 |
| Synonyms | DKFZp686H1544, FLJ45325, N-Shc, NSHC, RAI, SHCC |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9q22.1 |
| Summary | |
| Disorder | MIM: 605263 |
| mRNA | NM_016848, 302393565 |
| Protein | NP_058544, 224586793 |
| Product | SHC-transforming protein 3 |
| RefSeq Status | VALIDATED |
| hsa05214 | Glioma |
| hsa04062 | Chemokine signaling pathway |
| hsa04910 | Insulin signaling pathway |
| hsa04722 | Neurotrophin signaling pathway |
| hsa05220 | Chronic myeloid leukemia |
| hsa04012 | ErbB signaling pathway |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04510 | Focal adhesion |
Pathway Interaction Database
| trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
WikiPathways
| WP185 | Integrin-mediated cell adhesion |
| WP481 | Insulin Signaling |
| WP306 | Focal Adhesion |
Reactome
| REACT_999 | SHC-related events |
| REACT_12033 | Signalling to RAS |
| REACT_12058 | Signalling to ERKs |
| REACT_1195 | Insulin receptor signalling cascade |
| REACT_12056 | NGF signalling via TRKA from the plasma membrane |
| REACT_508 | Signal attenuation |
| REACT_661 | SHC-mediated signalling |
| REACT_11061 | Signalling by NGF |
| REACT_498 | Signaling by Insulin receptor |
| Homo sapiens (human) | SHC3 | NP_058544.3 |
| Pan troglodytes (chimpanzee) | SHC3 | XP_520118.2 |
| Canis lupus familiaris (dog) | SHC3 | XP_533553.2 |
| Bos taurus (cattle) | SHC3 | XP_590258.4 |
| Mus musculus (house mouse) | Shc3 | NP_033193.1 |
| Rattus norvegicus (Norway rat) | Shc3 | XP_341499.2 |
| Gallus gallus (chicken) | SHC3 | XP_428819.2 |
| Danio rerio (zebrafish) | LOC100332111 | XP_002665883.1 |
| Drosophila melanogaster (fruit fly) | Shc | NP_524683.2 |
| ID | Name | Evidence |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | TAS |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS |
| GO:0007265 | Ras protein signal transduction | EXP |
| GO:0007417 | central nervous system development | TAS |
| GO:0007611 | learning or memory | IEA |
| GO:0008286 | insulin receptor signaling pathway | TAS |
| GO:0035249 | synaptic transmission, glutamatergic | IEA |
| GO:0035556 | intracellular signal transduction | NAS |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS |
Component
| ID | Name | Evidence |
| GO:0005575 | cellular_component | ND |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0004871 | signal transducer activity | TAS |
| GO:0005515 | protein binding | IPI |
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