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PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18408D NM_000302 Homo sapiens procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1), mRNA. pcDNA3.1-C-(k)DYK On-demand 0 Starting from $99
OHu18408C NM_000302 Homo sapiens procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1), mRNA. Customized vector On-demand 0 Starting from $99

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Gene Symbol PLOD1
Entrez Gene ID 5351
Full Name procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Synonyms EDS6, LH, LH1, LLH, PLOD
General protein information
Preferred Names
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
lysine hydroxylase
lysyl hydroxlase 1
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008].

MIM: 153454

Ehlers-Danlos syndrome, type VI, 225400 (3); Nevo syndrome, 601451

mRNA Protein Product Sequence Price Select
NM_000302, 324710986 NP_000293, 32307144 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor ORF Sequence $700.00
hsa00310Lysine degradation
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_121139Collagen biosynthesis and modifying enzymes
Homo sapiens (human)PLOD1NP_000293.2
Pan troglodytes (chimpanzee)PLOD1XP_001142788.1
Canis lupus familiaris (dog)PLOD1XP_544565.2
Bos taurus (cattle)PLOD1NP_776573.1
Mus musculus (house mouse)Plod1NP_035252.1
Rattus norvegicus (Norway rat)Plod1NP_446279.2
Gallus gallus (chicken)PLOD1NP_001005618.1
Danio rerio (zebrafish)plod1aNP_001071210.2
Xenopus (Silurana) tropicalis (western clawed frog)plod1NP_001072340.1
GO:0001666response to hypoxiaIEP
GO:0006464cellular protein modification processNAS
GO:0008544epidermis developmentIMP
GO:0008544epidermis developmentTAS
GO:0030198extracellular matrix organizationTAS
GO:0046947hydroxylysine biosynthetic processTAS
GO:0055114oxidation-reduction processTAS
GO:0005789endoplasmic reticulum membraneTAS
GO:0030867rough endoplasmic reticulum membraneIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0005506iron ion bindingIEA
GO:0008475procollagen-lysine 5-dioxygenase activityIEA
GO:0031418L-ascorbic acid bindingIEA
GO:0042803protein homodimerization activityTAS
GeneCards PLOD1
UniProt Q02809
Vega OTTHUMG00000002393
MIM 153454
Ensembl ENSG00000083444
HGNC 9081
HPRD 01086

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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