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MAGEL2 MAGE-like 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20638 NM_019066 Homo sapiens MAGE-like 2 (MAGEL2), mRNA. pcDNA3.1+-DYK On-demand TBD $1699.00
OHu20638C NM_019066 Homo sapiens MAGE-like 2 (MAGEL2), mRNA. Customized vector On-demand TBD $1699.00

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Gene Symbol MAGEL2
Entrez Gene ID 54551
Full Name MAGE-like 2
Synonyms NDNL1, PWLS, nM15
General protein information
Preferred Names
MAGE-like protein 2
Names
MAGE-like protein 2
protein nM15
necdin-like protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q11-q12

Summary Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010].
Disorder

MIM: 605283

mRNA Protein Product Sequence Price Select
NM_019066, 257900507 NP_061939, 257900508 MAGE-like protein 2 ORF Sequence $1500.00
Homo sapiens (human)MAGEL2NP_061939.3
Macaca mulatta (Rhesus monkey)MAGEL2XP_001114423.2
Canis lupus familiaris (dog)LOC100684492XP_003434387.1
Bos taurus (cattle)MAGEL2XP_002696517.1
Mus musculus (house mouse)Magel2NP_038807.4
Rattus norvegicus (Norway rat)Magel2XP_001054803.2
Process
IDNameEvidence
GO:0008150biological_processND
GO:0034314Arp2/3 complex-mediated actin nucleationIDA
GO:0042147retrograde transport, endosome to GolgiIDA
GO:0070534protein K63-linked ubiquitinationIMP
Component
IDNameEvidence
GO:0005575cellular_componentND
GO:0005768endosomeIDA
GO:0005769early endosomeIEA
GO:0030904retromer complexIDA
Function
IDNameEvidence
GO:0003674molecular_functionND
GO:0004842ubiquitin-protein transferase activityIMP
GO:0005515protein bindingIPI
GeneCards MAGEL2
MIM 605283
HGNC 6814
HPRD 12008

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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