XAF1 XIAP associated factor 1 [Homo sapiens (human)]
| Gene Symbol | XAF1 |
| Entrez Gene ID | 54739 |
| Full Name | XIAP associated factor 1 |
| Synonyms | BIRC4BP, HSXIAPAF1, XIAPAF1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17p13.1 |
| Summary | X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM]. |
| Disorder | MIM: 606717 |
| mRNA | NM_017523, 40288190 |
| Protein | NP_059993, 40288191 |
| Product | XIAP-associated factor 1 isoform 1 |
| RefSeq Status | VALIDATED |
| mRNA | NM_199139, 40288192 |
| Protein | NP_954590, 40288193 |
| Product | XIAP-associated factor 1 isoform 2 |
| RefSeq Status | VALIDATED |
| REACT_25162 | Interferon alpha/beta signaling |
| REACT_6900 | Signaling in Immune system |
| REACT_25229 | Interferon Signaling |
| Homo sapiens (human) | XAF1 | NP_059993.2 |
| Pan troglodytes (chimpanzee) | XAF1 | XP_001168151.1 |
| Bos taurus (cattle) | XAF1 | NP_001030247.1 |
| Rattus norvegicus (Norway rat) | XAF1 | XP_001053682.1 |
| Gallus gallus (chicken) | XAF1 | XP_415922.2 |
| Danio rerio (zebrafish) | zgc:153893 | NP_001070115.1 |
| ID | Name | Evidence |
| GO:0006915 | apoptosis | IEA |
| GO:0019221 | cytokine-mediated signaling pathway | TAS |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005739 | mitochondrion | IEA |
Function
| ID | Name | Evidence |
| GO:0008270 | zinc ion binding | IEA |
| GO:0046872 | metal ion binding | IEA |
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