PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G [Homo sapiens (human)]
| Gene Symbol | PPM1G |
| Entrez Gene ID | 5496 |
| Full Name | protein phosphatase, Mg2+/Mn2+ dependent, 1G |
| Synonyms | MGC1675, MGC2870, PP2CG, PP2CGAMMA, PPP2CG |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
2 2p23.3 |
| Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 605119 |
| mRNA | NM_177983, 29826281 |
| Protein | NP_817092, 29826282 |
| Product | protein phosphatase 1G |
| RefSeq Status | REVIEWED |
| WP411 | mRNA processing |
| Homo sapiens (human) | PPM1G | NP_817092.1 |
| Pan troglodytes (chimpanzee) | PPM1G | XP_001156533.1 |
| Canis lupus familiaris (dog) | PPM1G | XP_532910.2 |
| Bos taurus (cattle) | PPM1G | NP_777226.2 |
| Mus musculus (house mouse) | Ppm1g | NP_032040.1 |
| Rattus norvegicus (Norway rat) | Ppm1g | NP_671742.1 |
| Danio rerio (zebrafish) | ppm1g | NP_958896.1 |
| Drosophila melanogaster (fruit fly) | CG10417 | NP_610169.1 |
| Caenorhabditis elegans | F42G9.1 | NP_741086.1 |
| ID | Name | Evidence |
| GO:0006470 | protein dephosphorylation | IEA |
| GO:0007050 | cell cycle arrest | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0008287 | protein serine/threonine phosphatase complex | IEA |
Function
| ID | Name | Evidence |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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